Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells = Ginkgetin의 항암효과

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dc.contributor.authorO H You-
dc.contributor.authorS H Kim-
dc.contributor.authorB Kim-
dc.contributor.authorE J Sohn-
dc.contributor.authorH J Lee-
dc.contributor.authorB S Shim-
dc.contributor.authorM Yun-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorS H Kim-
dc.date.accessioned2017-04-19T09:38:55Z-
dc.date.available2017-04-19T09:38:55Z-
dc.date.issued2013-
dc.identifier.issn0960894X-
dc.identifier.uri10.1016/j.bmcl.2013.02.080ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11284-
dc.description.abstractGinkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L. Though it was known to have anti-inflammatory, anti-influenza virus, anti-fungal activity, osteoblast differentiation stimulating activity and neuro-protective effects, the underlying antitumor mechanism of ginkgetin still remains unclear. Thus, in the present study, anti-cancer mechanism of ginkgetin was elucidated in human prostate cancer PC-3 cells. Ginkgetin suppressed the viability of PC-3 cells in a concentration-dependent manner and also significantly increased the sub-G1 DNA contents of cell cycle in PC-3 cells. Ginkgetin activated caspase-3 and attenuated the expression of survival genes such as Bcl-2, Bcl-xL, survivin and Cyclin D1 at protein and mRNA levels. Consistently, pan-caspase inhibitor Z-DEVD-fmk blocked sub G1 accumulation and cleavages of PRAP and caspase 3 induced by ginkgetin in PC-3 cells. Overall, these findings suggest that ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment.-
dc.publisherElsevier-
dc.titleGinkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells = Ginkgetin의 항암효과-
dc.title.alternativeGinkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number9-
dc.citation.endPage2695-
dc.citation.startPage2692-
dc.citation.volume23-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName유옥희-
dc.contributor.alternativeName김선희-
dc.contributor.alternativeName김봉리-
dc.contributor.alternativeName손은정-
dc.contributor.alternativeName이효정-
dc.contributor.alternativeName심범상-
dc.contributor.alternativeName윤미용-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName김성훈-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 23, no. 9, pp. 2692-2695-
dc.identifier.doi10.1016/j.bmcl.2013.02.080-
dc.subject.keywordApoptosis-
dc.subject.keywordCaspase-3-
dc.subject.keywordGinkgetin-
dc.subject.keywordPARP-
dc.subject.keywordPC-3 prostate cancer-
dc.subject.keywordSub-G1-
dc.subject.localApoptosis-
dc.subject.localCaspase-3-
dc.subject.localGinkgetin-
dc.subject.localPARP-
dc.subject.localPC-3 prostate cancer-
dc.subject.localSub-G1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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