DC Field | Value | Language |
---|---|---|
dc.contributor.author | D S Lee | - |
dc.contributor.author | Jae-Hyuk Jang | - |
dc.contributor.author | W Ko | - |
dc.contributor.author | K S Kim | - |
dc.contributor.author | J H Sohn | - |
dc.contributor.author | M S Kang | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.contributor.author | Y C Kim | - |
dc.contributor.author | Hyuncheol Oh | - |
dc.date.accessioned | 2017-04-19T09:39:02Z | - |
dc.date.available | 2017-04-19T09:39:02Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | 10.3390/md11041409 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11289 | - |
dc.description.abstract | Protein tyrosine phosphatase 1B (PTP1B) plays a major role in the negative regulation of insulin signaling, and is thus considered as an attractive therapeutic target for the treatment of diabetes. Bioassay-guided investigation of the methylethylketone extract of marine-derived fungus Penicillium sp. JF-55 cultures afforded a new PTP1B inhibitory styrylpyrone-type metabolite named penstyrylpyrone (1), and two known metabolites, anhydrofulvic acid (2) and citromycetin (3). Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, and kinetic analyses of PTP1B inhibition suggested that these compounds inhibited PTP1B activity in a competitive manner. In an effort to gain more biological potential of the isolated compounds, the anti-inflammatory effects of compounds 1-3 were also evaluated. Among the tested compounds, only compound 1 inhibited the production of NO and PGE2, due to the inhibition of the expression of iNOS and COX-2. Penstyrylpyrone (1) also reduced TNF-α and IL-1β production, and these anti-inflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of IκB-α, NF-κB nuclear translocation, and NF-κB DNA binding activity. In addition, using inhibitor tin protoporphyrin (SnPP), an inhibitor of HO-1, it was verified that the inhibitory effects of penstyrylpyrone (1) on the pro-inflammatory mediators and NF-κB DNA binding activity were associated with the HO-1 expression. Therefore, these results suggest that penstyrylpyrone (1) suppresses PTP1B activity, as well as the production of pro-inflammatory mediators via NF-κB pathway, through expression of anti-inflammatory HO-1. | - |
dc.publisher | MDPI | - |
dc.title | PTP1B inhibitory and anti-inflammatory effects of secondary metabolites isolated from the marine-derived fungus Penicillium sp. JF-55 | - |
dc.title.alternative | PTP1B inhibitory and anti-inflammatory effects of secondary metabolites isolated from the marine-derived fungus Penicillium sp. JF-55 | - |
dc.type | Article | - |
dc.citation.title | Marine Drugs | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 1426 | - |
dc.citation.startPage | 1409 | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 이동성 | - |
dc.contributor.alternativeName | 장재혁 | - |
dc.contributor.alternativeName | 고원민 | - |
dc.contributor.alternativeName | 김경수 | - |
dc.contributor.alternativeName | 손재학 | - |
dc.contributor.alternativeName | 강명석 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.contributor.alternativeName | 김연철 | - |
dc.contributor.alternativeName | 오현철 | - |
dc.identifier.bibliographicCitation | Marine Drugs, vol. 11, no. 4, pp. 1409-1426 | - |
dc.identifier.doi | 10.3390/md11041409 | - |
dc.subject.keyword | Anti-inflammatory effect | - |
dc.subject.keyword | Heme oxygenase-1 | - |
dc.subject.keyword | Marine-derived fungi | - |
dc.subject.keyword | Penicillium sp. | - |
dc.subject.keyword | PTP1B inhibitors | - |
dc.subject.local | Anti-Inflammatory Effect | - |
dc.subject.local | Anti-inflammatory effect | - |
dc.subject.local | anti-inflammatory effect | - |
dc.subject.local | Anti-inflammatory effects | - |
dc.subject.local | Heme oxygenase-1 | - |
dc.subject.local | Heme-oxygenase 1 | - |
dc.subject.local | Marine-derived fungi | - |
dc.subject.local | penicillium sp. | - |
dc.subject.local | Penicillium sp. | - |
dc.subject.local | PTP1B inhibitor | - |
dc.subject.local | PTP1B inhibitors | - |
dc.description.journalClass | Y | - |
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