DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung Ran Noh | - |
dc.contributor.author | Yong Hoon Kim | - |
dc.contributor.author | Jung Hwan Hwang | - |
dc.contributor.author | Gil Tae Gang | - |
dc.contributor.author | Kyoung Shim Kim | - |
dc.contributor.author | I K Lee | - |
dc.contributor.author | B S Yun | - |
dc.contributor.author | Chul Ho Lee | - |
dc.date.accessioned | 2017-04-19T09:39:06Z | - |
dc.date.available | 2017-04-19T09:39:06Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | 10.1016/j.fct.2013.04.005 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11294 | - |
dc.description.abstract | Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Davallialactone (DAVA), a hispidin analog derived from the mushroom Inonotus xeranticus, has antioxidant properties. This study evaluated whether DAVA plays protective roles against APAP hepatotoxicity in mice. Pretreatments with DAVA (10. mg/kg) prior to exposures of mice to a hepatotoxic dose of 600. mg/kg APAP significantly increased survival rate compared to APAP alone. To verify this effect, mice were treated with 400. mg/kg APAP 30. min after DAVA administration and were then sacrificed after 0.5, 1, 3, and 6. h. APAP alone caused severe liver injuries as characterized by increased plasma GOT and GPT levels, ATP and GSH depletion, and peroxynitrite and 4-HNE formations. These liver damages induced by APAP were significantly attenuated by DAVA pretreatments. The GSH/GSSG ratio nearly recovered to the levels observed in non-APAP-treated mice at 6. h after APAP treatment in DAVA-pretreated mice. Furthermore, while hepatic ROS levels were increased by APAP exposures, pretreatments with DAVA completely blocked ROS formation. In addition, APAP-induced sustained activations of JNK and ERK were remarkably reduced by DAVA pretreatment. In conclusion, these results suggest that DAVA plays protective roles against APAP-mediated hepatotoxicity through function as ROS scavenger. | - |
dc.publisher | Elsevier | - |
dc.title | Davallialactone protects against acetaminophen overdose-induced liver injuries in mice | - |
dc.title.alternative | Davallialactone protects against acetaminophen overdose-induced liver injuries in mice | - |
dc.type | Article | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 21 | - |
dc.citation.startPage | 14 | - |
dc.citation.volume | 58 | - |
dc.contributor.affiliatedAuthor | Jung Ran Noh | - |
dc.contributor.affiliatedAuthor | Yong Hoon Kim | - |
dc.contributor.affiliatedAuthor | Jung Hwan Hwang | - |
dc.contributor.affiliatedAuthor | Gil Tae Gang | - |
dc.contributor.affiliatedAuthor | Kyoung Shim Kim | - |
dc.contributor.affiliatedAuthor | Chul Ho Lee | - |
dc.contributor.alternativeName | 노정란 | - |
dc.contributor.alternativeName | 김용훈 | - |
dc.contributor.alternativeName | 황정환 | - |
dc.contributor.alternativeName | 강길태 | - |
dc.contributor.alternativeName | 김경심 | - |
dc.contributor.alternativeName | 이인경 | - |
dc.contributor.alternativeName | 윤봉식 | - |
dc.contributor.alternativeName | 이철호 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, vol. 58, no. 1, pp. 14-21 | - |
dc.identifier.doi | 10.1016/j.fct.2013.04.005 | - |
dc.subject.keyword | Acetaminophen | - |
dc.subject.keyword | Davallialactone | - |
dc.subject.keyword | Liver | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Toxicity | - |
dc.subject.local | Acetaminophen | - |
dc.subject.local | Davallialactone | - |
dc.subject.local | davallialactone | - |
dc.subject.local | liver | - |
dc.subject.local | Liver | - |
dc.subject.local | livers | - |
dc.subject.local | Oxidative stre | - |
dc.subject.local | Oxidative stress | - |
dc.subject.local | OXIDATIVE STRESS | - |
dc.subject.local | Oxidative Stress | - |
dc.subject.local | oxidative stress | - |
dc.subject.local | toxicity | - |
dc.subject.local | Toxicity | - |
dc.description.journalClass | Y | - |
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