Interspecific bacterial sensing through airborne signals modulates locomotion and drug resistance

Cited 73 time in scopus
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Title
Interspecific bacterial sensing through airborne signals modulates locomotion and drug resistance
Author(s)
Kwang-sun Kim; Soohyun LeeChoong-Min Ryu
Bibliographic Citation
Nature Communications, vol. 4, pp. 1809-1809
Publication Year
2013
Abstract
Bacteria use chemical signals to sense each other and to regulate various physiological functions. Although it is known that some airborne volatile organic compounds function as bacterial signalling molecules, their identities and effects on global gene expression and bacterial physiological processes remain largely unknown. Here we perform microarray analyses of Escherichia coli exposed to volatile organic compounds emitted from Bacillus subtilis. We find that 2,3-butanedione and glyoxylic acid mediate global changes in gene expression related to motility and antibiotic resistance. Volatile organic compound-dependent phenotypes are conserved among bacteria and are regulated by the previously uncharacterized ypdB gene product through the downstream transcription factors soxS, rpoS or yjhU. These results strongly suggest that bacteria use airborne volatile organic compounds to sense other bacteria and to change master regulatory gene activity to adapt
ISSN
2041-1723
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ncomms2789
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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