Comparison of prognostic genomic predictors in colorectal cancer

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dc.contributor.authorY Y Park-
dc.contributor.authorS S Lee-
dc.contributor.authorJ Y Lim-
dc.contributor.authorSang Cheol Kim-
dc.contributor.authorS B Kim-
dc.contributor.authorB H Sohn-
dc.contributor.authorIn-Sun Chu-
dc.contributor.authorS C Oh-
dc.contributor.authorE S Park-
dc.contributor.authorW Jeong-
dc.contributor.authorS S Kim-
dc.contributor.authorS Kopetz-
dc.contributor.authorJ S Lee-
dc.date.accessioned2017-04-19T09:39:26Z-
dc.date.available2017-04-19T09:39:26Z-
dc.date.issued2013-
dc.identifier.issn1932-6203-
dc.identifier.uri10.1371/journal.pone.0060778ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11305-
dc.description.abstractBackground: Although several prognostic genomic predictors have been identified from independent studies, it remains unclear whether these predictors are actually concordant with respect to their predictions for individual patients and which predictor performs best. We compared five prognostic genomic predictors, the V7RHS, the ColoGuideEx, the Meta163, the OncoDX, and the MDA114, in terms of predicting disease-free survival in two independent cohorts of patients with colorectal cancer. Study Design: Using original classification algorithms, we tested the predictions of five genomic predictors for disease-free survival in two cohorts of patients with colorectal cancer (n = 229 and n = 168) and evaluated concordance of predictors in predicting outcomes for individual patients. Results: We found that only two predictors, OncoDX and MDA114, demonstrated robust performance in identifying patients with poor prognosis in 2 independent cohorts. These two predictors also had modest but significant concordance of predicted outcome (r>0.3, P<0.001 in both cohorts). Conclusions: Further validation of developed genomic predictors is necessary. Despite the limited number of genes shared by OncoDX and MDA114, individual-patient outcomes predicted by these two predictors were significantly concordant.-
dc.publisherPublic Library of Science-
dc.titleComparison of prognostic genomic predictors in colorectal cancer-
dc.title.alternativeComparison of prognostic genomic predictors in colorectal cancer-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number4-
dc.citation.endPagee60778-
dc.citation.startPagee60778-
dc.citation.volume8-
dc.contributor.affiliatedAuthorSang Cheol Kim-
dc.contributor.affiliatedAuthorIn-Sun Chu-
dc.contributor.alternativeName박윤용-
dc.contributor.alternativeName이성숙-
dc.contributor.alternativeName임재윤-
dc.contributor.alternativeName김상철-
dc.contributor.alternativeName김상배-
dc.contributor.alternativeName손보화-
dc.contributor.alternativeName추인선-
dc.contributor.alternativeName오상철-
dc.contributor.alternativeName박은성-
dc.contributor.alternativeName정우진-
dc.contributor.alternativeName김성수-
dc.contributor.alternativeNameKopetz-
dc.contributor.alternativeName이주석-
dc.identifier.bibliographicCitationPLoS One, vol. 8, no. 4, pp. e60778-e60778-
dc.identifier.doi10.1371/journal.pone.0060778-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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