Synthesis and biological evaluation of novel aliphatic amidoquaternary ammonium salts for anticancer chemotherapy: part 2

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Title
Synthesis and biological evaluation of novel aliphatic amidoquaternary ammonium salts for anticancer chemotherapy: part 2
Author(s)
J S Yang; D Song; W J Ko; B Kim; Bo Kyung Kim; S K Park; Mi Sun Won; K Lee; K Lee; H M Kim; G Han
Bibliographic Citation
European Journal of Medicinal Chemistry, vol. 63, pp. 621-628
Publication Year
2013
Abstract
A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1- aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells.
Keyword
Aliphatic amido-quaternary ammonium saltsGTPase RAt Sarcoma (Ras)NSC126188PerifosinePiperazine alkyl derivativesRhoB
ISSN
0223-5234
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ejmech.2012.12.063
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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