Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug

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dc.contributor.authorYunhee Lee-
dc.contributor.authorM Lee-
dc.contributor.authorSemi Kim-
dc.date.accessioned2017-04-19T09:40:02Z-
dc.date.available2017-04-19T09:40:02Z-
dc.date.issued2013-
dc.identifier.issn0006291X-
dc.identifier.uri10.1016/j.bbrc.2013.03.082ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11330-
dc.description.abstractBinding of Gas6 to Axl (Gas6/Axl axis) alters cellular functions, including migration, invasion, proliferation, and survival. However, the molecular mechanisms underlying Gas6-mediated cell migration remain poorly understood. In this study, we found that Gas6 induced the activation of JNK and ERK1/2 signaling in cancer cells expressing Axl, resulting in the phosphorylation of activator protein-1 (AP-1) transcription factors c-Jun and ATF-2, and induction of Slug. Depletion of c-Jun or ATF-2 by siRNA attenuated the Gas6-induced expression of Slug. Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6. These results suggest that Gas6 induced cell migration via Slug upregulation in JNK- and ERK1/2-dependent mechanisms. These data provide an important insight into the molecular mechanisms mediating Gas6-induced cell migration.-
dc.publisherElsevier-
dc.titleGas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug-
dc.title.alternativeGas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage14-
dc.citation.startPage8-
dc.citation.volume434-
dc.contributor.affiliatedAuthorSemi Kim-
dc.contributor.alternativeName이윤희-
dc.contributor.alternativeName이미라-
dc.contributor.alternativeName김세미-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 434, no. 1, pp. 8-14-
dc.identifier.doi10.1016/j.bbrc.2013.03.082-
dc.subject.keywordEMT-
dc.subject.keywordGas6-
dc.subject.keywordMAPK-
dc.subject.keywordMigration-
dc.subject.keywordSlug-
dc.subject.localEMT-
dc.subject.localGas6-
dc.subject.localMAPK-
dc.subject.localMigration-
dc.subject.localSlug-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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