Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents

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dc.contributor.authorIk Jun Jo-
dc.contributor.authorChang Woo Lee-
dc.contributor.authorMyeong Youl Lee-
dc.contributor.authorMoo Rim Kang-
dc.contributor.authorJi Eun Yun-
dc.contributor.authorSoo Jin Oh-
dc.contributor.authorS B Han-
dc.contributor.authorK Lee-
dc.contributor.authorS K Park-
dc.contributor.authorH M Kim-
dc.contributor.authorS H Jung-
dc.contributor.authorJong Soon Kang-
dc.date.accessioned2017-04-19T09:40:13Z-
dc.date.available2017-04-19T09:40:13Z-
dc.date.issued2013-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2013.05.008ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11342-
dc.description.abstractIn the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammatory effect of S(+)-zaltoprofen was stronger than that of racemic zaltoprofen, suggesting that S(+)-zaltoprofen is an active component of racemic zaltoprofen in terms of anti-inflammatory activity. In contrast, the results of acetic acid-induced writhing model demonstrated that no significant analgesic effect was observed by racemic zaltoprofen and zaltoprofen enantiomers at doses used in carrageenan-induced paw edema model. However, racemic zaltoprofen and zaltoprofen enantiomers all exerted an analgesic effect at higher doses, which is inconsistent with the result of carrageenan-induced paw edema model. Gastric ulcers induced by racemic zaltoprofen and zaltoprofen enantiomers were minimal. Taken together, these results suggest that S(+)-zaltoprofen is a potent and active anti-inflammatory component of racemic zaltoprofen, but both S(+)-zaltoprofen and R(-)-zaltoprofen might seem to contribute to the analgesic effect of racemic zaltoprofen.-
dc.publisherElsevier-
dc.titleDifferential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents-
dc.title.alternativeDifferential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number4-
dc.citation.endPage460-
dc.citation.startPage457-
dc.citation.volume16-
dc.contributor.affiliatedAuthorIk Jun Jo-
dc.contributor.affiliatedAuthorChang Woo Lee-
dc.contributor.affiliatedAuthorMyeong Youl Lee-
dc.contributor.affiliatedAuthorMoo Rim Kang-
dc.contributor.affiliatedAuthorJi Eun Yun-
dc.contributor.affiliatedAuthorSoo Jin Oh-
dc.contributor.affiliatedAuthorJong Soon Kang-
dc.contributor.alternativeName조익준-
dc.contributor.alternativeName이창우-
dc.contributor.alternativeName이명열-
dc.contributor.alternativeName강무림-
dc.contributor.alternativeName윤지은-
dc.contributor.alternativeName오수진-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName이기호-
dc.contributor.alternativeName박성규-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName정상훈-
dc.contributor.alternativeName강종순-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 16, no. 4, pp. 457-460-
dc.identifier.doi10.1016/j.intimp.2013.05.008-
dc.subject.keywordAnalgesic-
dc.subject.keywordAnti-inflammatory-
dc.subject.keywordEnantiomer-
dc.subject.keywordZaltoprofen-
dc.subject.localAnalgesic-
dc.subject.localanti-inflammatory-
dc.subject.localAnti-inflammatory-
dc.subject.localEnantiomer-
dc.subject.localEnantiomers-
dc.subject.localZaltoprofen-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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