Triterpenes with cytotoxicity from the leaves of Vernicia fordii = 유동잎의 세포독성을 갖는 트리테르펜 화합물

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Title
Triterpenes with cytotoxicity from the leaves of Vernicia fordii = 유동잎의 세포독성을 갖는 트리테르펜 화합물
Author(s)
Y H Pei; Ok-Kyoung Kwon; J S Lee; H J Cha; Kyung Seop AhnSei-Ryang Oh; Hyeong Kyu Lee; Y W Chin
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 61, no. 6, pp. 674-677
Publication Year
2013
Abstract
Two new triterpenes, (1α,3β,8α,9β,10α, 13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma).
Keyword
CytotoxicityTriterpeneVernicia fordii
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.c13-00055
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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