Electrotriggered, spatioselective, quantitative gene delivery into a single cell nucleus by Au nanowire nanoinjector

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dc.contributor.authorS M Yoo-
dc.contributor.authorM Kang-
dc.contributor.authorTaejoon Kang-
dc.contributor.authorD M Kim-
dc.contributor.authorS Y Lee-
dc.contributor.authorB Kim-
dc.date.accessioned2017-04-19T09:40:20Z-
dc.date.available2017-04-19T09:40:20Z-
dc.date.issued2013-
dc.identifier.issn1530-6984-
dc.identifier.uri10.1021/nl4003393ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11362-
dc.description.abstractDelivery of bioactive materials into a cell is highly important in the study of cell biology and medical treatments. Ideal nanoinjectors should be able to deliver biomaterials with high spatial resolution while causing minimum cell damage. We developed a Au nanowire (NW) nanoinjector that has the thinnest diameter (100-150 nm) among the DNA delivering devices as well as optimum mechanical properties, minimizing cell damage. Well-defined (111) single-crystalline Au surface and high electric conductivity of a Au NW nanoinjector allow precisely timed and efficient electrochemical release of DNA molecules attached on a Au NW surface. Both linear DNA and plasmid DNA were delivered separately and showed successful expression. The Au NW nanoinjector would find important biomedical applications in the fields such as gene therapy, DNA vaccination, targeted drug delivery, and probe/control of cell signaling events.-
dc.publisherAmer Chem Soc-
dc.titleElectrotriggered, spatioselective, quantitative gene delivery into a single cell nucleus by Au nanowire nanoinjector-
dc.title.alternativeElectrotriggered, spatioselective, quantitative gene delivery into a single cell nucleus by Au nanowire nanoinjector-
dc.typeArticle-
dc.citation.titleNano Letters-
dc.citation.number6-
dc.citation.endPage2435-
dc.citation.startPage2431-
dc.citation.volume13-
dc.contributor.affiliatedAuthorTaejoon Kang-
dc.contributor.alternativeName유승민-
dc.contributor.alternativeName강미정-
dc.contributor.alternativeName강태준-
dc.contributor.alternativeName김동민-
dc.contributor.alternativeName이상엽-
dc.contributor.alternativeName김봉수-
dc.identifier.bibliographicCitationNano Letters, vol. 13, no. 6, pp. 2431-2435-
dc.identifier.doi10.1021/nl4003393-
dc.subject.keywordAu nanowire-
dc.subject.keywordDNA-
dc.subject.keywordelectrical trigger-
dc.subject.keywordgene delivery-
dc.subject.keywordnanoinject-
dc.subject.localAu nanowire-
dc.subject.localDNA-
dc.subject.localelectrical trigger-
dc.subject.localgene delivery-
dc.subject.localGene delivery-
dc.subject.localnanoinject-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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