iNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation

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dc.contributor.authorYoung-Ho Park-
dc.contributor.authorH J Shin-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorJ M Kim-
dc.contributor.authorJ H Kim-
dc.contributor.authorD H Bang-
dc.contributor.authorKyu Tae Chang-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorDae Yeul Yu-
dc.date.accessioned2017-04-19T09:40:29Z-
dc.date.available2017-04-19T09:40:29Z-
dc.date.issued2013-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2013.04.071ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11375-
dc.description.abstractInducible nitric oxide (iNOS) is closely correlated with chronic inflammation in hepatitis B virus X protein (HBx)-induced hepatocellular carcinoma (HCC). However, the molecular mechanisms through which iNOS contribute to hepatocarcinogenesis remain poorly understood. Therefore, we investigated the role of iNOS in signaling pathways underlying HBx-induced liver tumorigenesis. iNOS deletion showed a marked decrease in the hepatic tumor size and stage of HBx transgenic (Tg) mice, indicating a strong contribution of iNOS signaling pathways to hepatocarcinogenesis. In addition, we found that nitric oxide (NO) increased HBx mRNA by recruiting CREB to the CRE site of HBV enhancer in HepG2 cells, suggesting a positive feedback loop between HBx and iNOS signaling pathway. Moreover, iNOS-modulated JNK activation was associated with sustained upregulation of Cyclin D1 in HBxTg mice and HepG2-. HBx cells. These results imply that iNOS may play a key role in HBx-associated HCC development. Taken together, our findings demonstrate that iNOS aligns with HBx to promote tumor progression. These findings provide a better understating of the mechanism involving HBx-mediated hepatic tumorigenesis and selective inhibition of iNOS may have therapeutic applications in HBx-associated HCC.-
dc.publisherElsevier-
dc.titleiNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation-
dc.title.alternativeiNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage249-
dc.citation.startPage244-
dc.citation.volume435-
dc.contributor.affiliatedAuthorYoung-Ho Park-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeName박영호-
dc.contributor.alternativeName신혜준-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName김진만-
dc.contributor.alternativeName김주현-
dc.contributor.alternativeName방동호-
dc.contributor.alternativeName장규태-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName유대열-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 435, no. 2, pp. 244-249-
dc.identifier.doi10.1016/j.bbrc.2013.04.071-
dc.subject.keywordHBx-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordINOS-
dc.subject.keywordJNK-
dc.subject.localHBX-
dc.subject.localHBx-
dc.subject.localHepatocellular carcinomas-
dc.subject.localHepatocellular carcinoma (HCC)-
dc.subject.localHepatocellular carcinoma-
dc.subject.localhepatocellular carcinoma (HCC)-
dc.subject.localhepatocellular carcinoma-
dc.subject.localInducible nitric oxide synthase (iNOS)-
dc.subject.localInducible nitric oxide synthase-
dc.subject.localinducible nnitric oxide synthase-
dc.subject.localiNOS-
dc.subject.localInducible nitric oxide synthease (iNOS)-
dc.subject.localINOS-
dc.subject.localinducible nitric oxide synthase-
dc.subject.localJNK-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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