Virtual screening and biochemical evaluation of the inhibitors of dual-specificity phosphatase 26 = DUSP26 저해제의 가상검색과 생화학적 평가

Cited 3 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorH Park-
dc.contributor.authorAyoung Gyeong-
dc.contributor.authorH J Lee-
dc.contributor.authorSunghyun Kang-
dc.contributor.authorTae-Sung Yoon-
dc.contributor.authorS E Ryu-
dc.contributor.authorDae Gwin Jeong-
dc.date.accessioned2017-04-19T09:40:32Z-
dc.date.available2017-04-19T09:40:32Z-
dc.date.issued2013-
dc.identifier.issn1054-2523-
dc.identifier.uri10.1007/s00044-012-0405-3ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11377-
dc.description.abstractDual-specificity phosphatase 26 (DUSP26) has recently proved to be a promising therapeutical target for the treatment of human cancers. Here, we report the first example for a successful application of the structure-based virtual screening approach to identify nine novel inhibitors of DUSP26. These inhibitors are also screened for having desirable physicochemical properties as drug candidates and reveal a high potency with IC50 values ranging from 8 to 42 μM. Therefore, they deserve consideration for further development by structure-activity relationship (SAR) studies to optimize the anticancer activities. Structural features relevant to the stabilization of the newly identified inhibitors in the active site of DUSP26 are addressed in detail.-
dc.publisherSpringer-
dc.titleVirtual screening and biochemical evaluation of the inhibitors of dual-specificity phosphatase 26 = DUSP26 저해제의 가상검색과 생화학적 평가-
dc.title.alternativeVirtual screening and biochemical evaluation of the inhibitors of dual-specificity phosphatase 26-
dc.typeArticle-
dc.citation.titleMedicinal Chemistry Research-
dc.citation.number8-
dc.citation.endPage3910-
dc.citation.startPage3905-
dc.citation.volume22-
dc.contributor.affiliatedAuthorAyoung Gyeong-
dc.contributor.affiliatedAuthorSunghyun Kang-
dc.contributor.affiliatedAuthorTae-Sung Yoon-
dc.contributor.affiliatedAuthorDae Gwin Jeong-
dc.contributor.alternativeName박황서-
dc.contributor.alternativeName경아영-
dc.contributor.alternativeName이현주-
dc.contributor.alternativeName강성현-
dc.contributor.alternativeName윤태성-
dc.contributor.alternativeName류성언-
dc.contributor.alternativeName정대균-
dc.identifier.bibliographicCitationMedicinal Chemistry Research, vol. 22, no. 8, pp. 3905-3910-
dc.identifier.doi10.1007/s00044-012-0405-3-
dc.subject.keywordAnticancer agents-
dc.subject.keywordDocking-
dc.subject.keywordDUSP26-
dc.subject.keywordInhibitor-
dc.subject.keywordVirtual screening-
dc.subject.localAnticancer Agents-
dc.subject.localAnti-cancer agents-
dc.subject.localanti-cancer agent-
dc.subject.localAnti-cancer agent-
dc.subject.localAnticancer agent-
dc.subject.localAnticancer agents-
dc.subject.localAnticancer Agent-
dc.subject.localanticancer agent-
dc.subject.localdocking-
dc.subject.localDocking-
dc.subject.localDUSP26-
dc.subject.localinhibitors-
dc.subject.localInhibitors-
dc.subject.localinhibitor-
dc.subject.localInhibitor-
dc.subject.localVirtual screening-
dc.description.journalClassY-
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.