Bimodal perfluorocarbon nanoemulsions for nasopharyngeal carcinoma targeting

Cited 16 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorPan Kee Bae-
dc.contributor.authorJuyeon Jung-
dc.contributor.authorS J Lim-
dc.contributor.authorD Kim-
dc.contributor.authorS K Kim-
dc.contributor.authorBong Hyun Chung-
dc.date.accessioned2017-04-19T09:40:33Z-
dc.date.available2017-04-19T09:40:33Z-
dc.date.issued2013-
dc.identifier.issn15361632-
dc.identifier.uri10.1007/s11307-013-0622-2ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11382-
dc.description.abstractPurpose: The aim of this study was to perform the detection of folate receptor (FR)-positive tumors with a bimodal imaging contrast agent, a perfluorocarbon (PFC)/rhodamine nanoemulsion, providing both 19F-based magnetic resonance imaging (MRI) and fluorescence imaging capabilities. Procedures: The PFC/rhodamine nanoemulsion was further infused with phospholipid-anchored folate to improve the ability to target FR-expressing tumors. The preferential accumulation of the FR-targeted bimodal nanoemulsion in FR-positive tumor sites was monitored by both 19F-MRI and optical imaging. Results: The FR-targeted PFC nanoemulsion had no significant effect on cell viability, and the size and fluorescence signal of PFC nanoemulsion were very stable. These nanoprobes were successfully delivered into FR-positive tumor xenograft models and showed significantly enhanced signal intensities of 19F-MRI and fluorescence imaging in the tumor area. Conclusions: The folate-PFC/rhodamine nanoemulsion has a great potential to serve as a useful optical and 19F-MRI agent for the diagnosis and targeting of FR-positive tumor.-
dc.publisherSpringer-
dc.titleBimodal perfluorocarbon nanoemulsions for nasopharyngeal carcinoma targeting-
dc.title.alternativeBimodal perfluorocarbon nanoemulsions for nasopharyngeal carcinoma targeting-
dc.typeArticle-
dc.citation.titleMolecular Imaging and Biology-
dc.citation.number4-
dc.citation.endPage410-
dc.citation.startPage401-
dc.citation.volume15-
dc.contributor.affiliatedAuthorJuyeon Jung-
dc.contributor.alternativeName배판기-
dc.contributor.alternativeName정주연-
dc.contributor.alternativeName임수진-
dc.contributor.alternativeName김대홍-
dc.contributor.alternativeName김석기-
dc.contributor.alternativeName정봉현-
dc.identifier.bibliographicCitationMolecular Imaging and Biology, vol. 15, no. 4, pp. 401-410-
dc.identifier.doi10.1007/s11307-013-0622-2-
dc.subject.keyword19F-MR-
dc.subject.keywordBimodal nanoemulsion-
dc.subject.keywordCancer-
dc.subject.keywordCancer-specific imaging-
dc.subject.keywordMRI-
dc.subject.keywordOptical imaging-
dc.subject.keywordPerfluorocarbon-
dc.subject.local19F-MR-
dc.subject.localBimodal nanoemulsion-
dc.subject.localCancer-
dc.subject.localCancer-specific imaging-
dc.subject.localMRI-
dc.subject.localMagnetic resonance imaging (MRI)-
dc.subject.localOptical imaging-
dc.subject.localPerfluorocarbon-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.