TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress

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dc.contributor.authorHaiyoung Jung-
dc.contributor.authorMi Jeong Kim-
dc.contributor.authorDongoh Kim-
dc.contributor.authorWon Sam Kim-
dc.contributor.authorSung Jin Yoon-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorTae-Don Kim-
dc.contributor.authorHyun Woo Suh-
dc.contributor.authorSohyun Yun-
dc.contributor.authorJeong Ki Min-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorY H Lee-
dc.contributor.authorH J Na-
dc.contributor.authorDong Chul Lee-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorIn Pyo Choi-
dc.date.accessioned2017-04-19T09:40:34Z-
dc.date.available2017-04-19T09:40:34Z-
dc.date.issued2013-
dc.identifier.issn1550-4131-
dc.identifier.uri10.1016/j.cmet.2013.06.002ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11386-
dc.description.abstractReactive oxygen species (ROS) are critical determinants of the fate of hematopoietic stem cells (HSCs) and hematopoiesis. Thioredoxin-interacting protein (TXNIP), which is induced by oxidative stress, is a known regulator of intracellular ROS. Txnip-/- old mice exhibited elevated ROS levels in hematopoietic cells and showed a reduction in hematopoietic cell population. Loss of TXNIP led to a dramatic reduction of mouse survival under oxidative stress. TXNIP directly regulated p53 protein by interfering with p53- mouse double minute 2 (MDM2) interactions and increasing p53 transcriptional activity. Txnip-/- mice showed downregulation of the antioxidant genes induced by p53. Introduction of TXNIP or p53 into Txnip-/- bone marrow cells rescued the HSC frequency and greatly increased survival in mice following oxidative stress. Overall, these data indicate that TXNIP is a regulator of p53 and plays a pivotal role in the maintenance of the hematopoietic cells by regulating intracellular ROS during oxidative stress-
dc.publisherElsevier-Cell Press-
dc.titleTXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress-
dc.title.alternativeTXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress-
dc.typeArticle-
dc.citation.titleCell Metabolism-
dc.citation.number1-
dc.citation.endPage85-
dc.citation.startPage75-
dc.citation.volume18-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.affiliatedAuthorMi Jeong Kim-
dc.contributor.affiliatedAuthorDongoh Kim-
dc.contributor.affiliatedAuthorWon Sam Kim-
dc.contributor.affiliatedAuthorSung Jin Yoon-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorTae-Don Kim-
dc.contributor.affiliatedAuthorSohyun Yun-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorDong Chul Lee-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.alternativeName정해용-
dc.contributor.alternativeName김미정-
dc.contributor.alternativeName김동오-
dc.contributor.alternativeName김원삼-
dc.contributor.alternativeName윤성진-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName김태돈-
dc.contributor.alternativeName서현우-
dc.contributor.alternativeName윤소현-
dc.contributor.alternativeName민정기-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName이용호-
dc.contributor.alternativeName나희준-
dc.contributor.alternativeName이동철-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName최인표-
dc.identifier.bibliographicCitationCell Metabolism, vol. 18, no. 1, pp. 75-85-
dc.identifier.doi10.1016/j.cmet.2013.06.002-
dc.description.journalClassY-
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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