DC Field | Value | Language |
---|---|---|
dc.contributor.author | Haiyoung Jung | - |
dc.contributor.author | Mi Jeong Kim | - |
dc.contributor.author | Dongoh Kim | - |
dc.contributor.author | Won Sam Kim | - |
dc.contributor.author | Sung Jin Yoon | - |
dc.contributor.author | Young-Jun Park | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | Tae-Don Kim | - |
dc.contributor.author | Hyun Woo Suh | - |
dc.contributor.author | Sohyun Yun | - |
dc.contributor.author | Jeong Ki Min | - |
dc.contributor.author | Hee Gu Lee | - |
dc.contributor.author | Y H Lee | - |
dc.contributor.author | H J Na | - |
dc.contributor.author | Dong Chul Lee | - |
dc.contributor.author | Hyoung-Chin Kim | - |
dc.contributor.author | In Pyo Choi | - |
dc.date.accessioned | 2017-04-19T09:40:34Z | - |
dc.date.available | 2017-04-19T09:40:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1550-4131 | - |
dc.identifier.uri | 10.1016/j.cmet.2013.06.002 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11386 | - |
dc.description.abstract | Reactive oxygen species (ROS) are critical determinants of the fate of hematopoietic stem cells (HSCs) and hematopoiesis. Thioredoxin-interacting protein (TXNIP), which is induced by oxidative stress, is a known regulator of intracellular ROS. Txnip-/- old mice exhibited elevated ROS levels in hematopoietic cells and showed a reduction in hematopoietic cell population. Loss of TXNIP led to a dramatic reduction of mouse survival under oxidative stress. TXNIP directly regulated p53 protein by interfering with p53- mouse double minute 2 (MDM2) interactions and increasing p53 transcriptional activity. Txnip-/- mice showed downregulation of the antioxidant genes induced by p53. Introduction of TXNIP or p53 into Txnip-/- bone marrow cells rescued the HSC frequency and greatly increased survival in mice following oxidative stress. Overall, these data indicate that TXNIP is a regulator of p53 and plays a pivotal role in the maintenance of the hematopoietic cells by regulating intracellular ROS during oxidative stress | - |
dc.publisher | Elsevier-Cell Press | - |
dc.title | TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress | - |
dc.title.alternative | TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress | - |
dc.type | Article | - |
dc.citation.title | Cell Metabolism | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 85 | - |
dc.citation.startPage | 75 | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Haiyoung Jung | - |
dc.contributor.affiliatedAuthor | Mi Jeong Kim | - |
dc.contributor.affiliatedAuthor | Dongoh Kim | - |
dc.contributor.affiliatedAuthor | Won Sam Kim | - |
dc.contributor.affiliatedAuthor | Sung Jin Yoon | - |
dc.contributor.affiliatedAuthor | Young-Jun Park | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | Tae-Don Kim | - |
dc.contributor.affiliatedAuthor | Sohyun Yun | - |
dc.contributor.affiliatedAuthor | Jeong Ki Min | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.affiliatedAuthor | Dong Chul Lee | - |
dc.contributor.affiliatedAuthor | Hyoung-Chin Kim | - |
dc.contributor.affiliatedAuthor | In Pyo Choi | - |
dc.contributor.alternativeName | 정해용 | - |
dc.contributor.alternativeName | 김미정 | - |
dc.contributor.alternativeName | 김동오 | - |
dc.contributor.alternativeName | 김원삼 | - |
dc.contributor.alternativeName | 윤성진 | - |
dc.contributor.alternativeName | 박영준 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 김태돈 | - |
dc.contributor.alternativeName | 서현우 | - |
dc.contributor.alternativeName | 윤소현 | - |
dc.contributor.alternativeName | 민정기 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.contributor.alternativeName | 이용호 | - |
dc.contributor.alternativeName | 나희준 | - |
dc.contributor.alternativeName | 이동철 | - |
dc.contributor.alternativeName | 김형진 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.identifier.bibliographicCitation | Cell Metabolism, vol. 18, no. 1, pp. 75-85 | - |
dc.identifier.doi | 10.1016/j.cmet.2013.06.002 | - |
dc.description.journalClass | Y | - |
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