Cited 49 time in
- Title
- Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway
- Author(s)
- Young-Ho Park; Sun-Uk Kim; Bo Kyoung Lee; H S Kim; I S Song; Hye Jun Shin; Y H Han; Kyu Tae Chang; J M Kim; D S Lee; Y H Kim; C M Choi; Bo Yeon Kim; Dae Yeul Yu
- Bibliographic Citation
- Antioxidants & Redox Signaling, vol. 19, no. 5, pp. 482-496
- Publication Year
- 2013
- Abstract
- Aims: Coupled responses of mutated K-ras and oxidative stress are often an important etiological factor in non-small-cell lung cancer (NSCLC). However, relatively few studies have examined the control mechanism of oxidative stress in oncogenic K-ras-driven NSCLC progression. Here, we studied whether the redox signaling pathway governed by peroxiredoxin I (Prx I) is involved in K-ras G12D-mediated lung adenocarcinogenesis. Results: Using human-lung adenocarcinoma tissues and lung-specific K-rasG12D-transgenic mice, we found that Prx I was significantly up-regulated in the tumor regions via activation of nuclear erythroid 2-related factor 2 (Nrf2) transcription. Interestingly, the increased reactive oxygen species (ROS) by null mutation of Prx I greatly promoted K-rasG12D-driven lung tumorigenesis in number and size, which appeared to require the activation of the ROS-dependent extracellular signal-regulated kinase (ERK)/cyclin D1 pathway. Innovation: Taken together, these results suggest that Prx I functions as an Nrf2-dependently inducible tumor suppressant in K-ras-driven lung adenocarcinogenesis by opposing ROS/ERK/cyclin D1 pathway activation. Conclusion: These findings provide a better understanding of oxidative stress-mediated lung tumorigenesis.
- ISSN
- 1523-0864
- Publisher
- Mary Ann Liebert, Inc
- DOI
- http://dx.doi.org/10.1089/ars.2011.4421
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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