Synthesis, structure-activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors = STAT3 활성 저해제 및 구조-활성 관계 규명

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dc.contributor.authorD Masciocchi-
dc.contributor.authorA Gelain-
dc.contributor.authorF Porta-
dc.contributor.authorF Meneghetti-
dc.contributor.authorA Pedretti-
dc.contributor.authorG Celentano-
dc.contributor.authorD Barlocco-
dc.contributor.authorL Legnani-
dc.contributor.authorL Toma-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorA Asaid-
dc.contributor.authorS Villa-
dc.date.accessioned2017-04-19T09:40:59Z-
dc.date.available2017-04-19T09:40:59Z-
dc.date.issued2013-
dc.identifier.issn2040-2503-
dc.identifier.uri10.1039/c3md00095hko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11396-
dc.description.abstractThrough a cell-based biological screening, the benzocinnolinone derivative (±)-2c was identified as a promising STAT3 inhibitor. Since SAR studies on a series of compounds structurally related to (±)-2c (1c, 2a-p, 3c, 4c, 6) showed that the latter had the most significant inhibitory activity, we investigated in depth its essential structural features. In particular, enantiomeric separation was performed, and the absolute configuration of the stereoisomers was assigned by theoretical and crystallographic studies. The biological evaluation highlighted that (S)-(-)-2c is twice as potent as (R)-(+)-2c.-
dc.publisherRoyal Soc Chemistry-
dc.titleSynthesis, structure-activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors = STAT3 활성 저해제 및 구조-활성 관계 규명-
dc.title.alternativeSynthesis, structure-activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors-
dc.typeArticle-
dc.citation.titleMedchemcomm-
dc.citation.number8-
dc.citation.endPage1188-
dc.citation.startPage1181-
dc.citation.volume4-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeNameMasciocchi-
dc.contributor.alternativeNameGelain-
dc.contributor.alternativeNamePorta-
dc.contributor.alternativeNameMeneghetti-
dc.contributor.alternativeNamePedretti-
dc.contributor.alternativeNameCelentano-
dc.contributor.alternativeNameBarlocco-
dc.contributor.alternativeNameLegnani-
dc.contributor.alternativeNameToma-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeNameAsaid-
dc.contributor.alternativeNameVilla-
dc.identifier.bibliographicCitationMedchemcomm, vol. 4, no. 8, pp. 1181-1188-
dc.identifier.doi10.1039/c3md00095h-
dc.description.journalClassN-
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