Biological features of core networks that result from a high-fat diet in hepatic and pulmonary tissues in mammary tumour-bearing, obesity-resistant mice

Cited 7 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorE J Kim-
dc.contributor.authorHea-Young Oh-
dc.contributor.authorH S Heo-
dc.contributor.authorJ E Hong-
dc.contributor.authorS J Jung-
dc.contributor.authorK W Lee-
dc.contributor.authorJ H Park-
dc.contributor.authorCheol-Goo Hur-
dc.contributor.authorJ H Y Park-
dc.description.abstractWe previously demonstrated that the chronic consumption of a high-fat diet (HFD) promotes lung and liver metastases of 4T1 mammary carcinoma cells in obesity-resistant BALB/c mice. To examine early transcriptional responses to tumour progression in the liver and lungs of HFD-fed mice, 4-week-old female BALB/c mice were divided into four groups: sham-injected, control diet (CD)-fed; sham-injected, HFD-fed (SH); 4T1 cell-injected, CD-fed (TC); 4T1 cell-injected, HFD-fed (TH). Following 16 weeks of either a CD or HFD, 4T1 cells were injected into the mammary fat pads of mice in the TC and TH groups and all mice were continuously fed identical diets. At 14A d post-injection, RNA was isolated from hepatic and pulmonary tissues for microarray analysis of mRNA expression. Functional annotation and core network analyses were conducted for the TH/SH Unique gene set. Inflammation in hepatic tissues and cell mitosis in pulmonary tissues were the most significant biological functions in the TH/SH Unique gene set. The biological core networks of the hepatic TH/SH Unique gene set were characterised as those genes involved in the activation of acute inflammatory responses (Orm1, Lbp, Hp and Cfb), disordered lipid metabolism and deregulated cell cycle progression. Networks of the pulmonary Unique gene set displayed the deregulation of cell cycle progression (Cdc20, Cdk1 and Bub1b). These HFD-influenced alterations may have led to favourable conditions for the formation of both pro-inflammatory and pro-mitotic microenvironments in the target organs that promote immune cell infiltration and differentiation, as well as the infiltration and proliferation of metastatic tumour cells.-
dc.publisherCambridge Univ Press-
dc.titleBiological features of core networks that result from a high-fat diet in hepatic and pulmonary tissues in mammary tumour-bearing, obesity-resistant mice-
dc.title.alternativeBiological features of core networks that result from a high-fat diet in hepatic and pulmonary tissues in mammary tumour-bearing, obesity-resistant mice-
dc.citation.titleBritish Journal of Nutrition-
dc.contributor.affiliatedAuthorHea-Young Oh-
dc.contributor.affiliatedAuthorCheol-Goo Hur-
dc.identifier.bibliographicCitationBritish Journal of Nutrition, vol. 110, no. 2, pp. 241-255-
dc.subject.keyword4T1 mammary tumours-
dc.subject.keywordBALB/c mice-
dc.subject.keywordDifferentially expressed genes-
dc.subject.keywordHigh-fat diet-
dc.subject.local4T1 mammary tumours-
dc.subject.localBALB/c mice-
dc.subject.localDifferentially expressed genes-
dc.subject.localDifferentially expressed genes (DEGs)-
dc.subject.localDifferentially expressed gene-
dc.subject.localdifferentially expressed genes-
dc.subject.localHigh-fat diet-
dc.subject.localhigh-fat diet-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.