DC Field | Value | Language |
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dc.contributor.author | Yuri Jung | - |
dc.contributor.author | Y J Jang | - |
dc.contributor.author | Min Ho Kang | - |
dc.contributor.author | Young Soo Park | - |
dc.contributor.author | Su Jin Oh | - |
dc.contributor.author | Dong Chul Lee | - |
dc.contributor.author | Z Xie | - |
dc.contributor.author | H S Yoo | - |
dc.contributor.author | Kyung Chan Park | - |
dc.contributor.author | Young Il Yeom | - |
dc.date.accessioned | 2017-04-19T09:41:30Z | - |
dc.date.available | 2017-04-19T09:41:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | 10.1007/s10059-013-2319-4 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11431 | - |
dc.description.abstract | Pyruvate kinase, muscle type 2 (PKM2), is a key factor in the aerobic glycolysis of cancer cells. In our experiments, liver cancer cell lines exhibited a range of sensitivity to PKM2 knockdown-mediated growth inhibition. We speculated that this differential sensitivity is attributable to the variable dependency on glycolysis for the growth of different cell lines. Transcriptome data revealed overexpression of a glucose transporter (GLUT3) and a lactate transporter (MCT4) genes in PKM2 knockdown-sensitive cells. PKM2 knockdown-resistant cells expressed high levels of the lactate dehydrogenase B (LDHB) and glycine decarboxylase (GLDC) genes. Concordant with the gene expression results, PKM2 knockdown-sensitive cells generated high levels of lactate. In addition, ATP production was significantly reduced in the PKM2 knockdown-sensitive cells treated with a glucose analog, indicative of dependency of their cellular energetics on lactate-producing glycolysis. The PKM2 knockdown-resistant cells were further subdivided into less glycolytic and more (glycolysis branch pathway-dependent) glycolytic groups. Our findings collectively support the utility of PKM2 as a therapeutic target for high lactate-producing glycolytic hepatocellular carcinoma (HCC). | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells | - |
dc.title.alternative | Metabolic signature genes associated with susceptibility to pyruvate kinase, muscle type 2 gene ablation in cancer cells | - |
dc.type | Article | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 341 | - |
dc.citation.startPage | 335 | - |
dc.citation.volume | 35 | - |
dc.contributor.affiliatedAuthor | Yuri Jung | - |
dc.contributor.affiliatedAuthor | Min Ho Kang | - |
dc.contributor.affiliatedAuthor | Young Soo Park | - |
dc.contributor.affiliatedAuthor | Su Jin Oh | - |
dc.contributor.affiliatedAuthor | Dong Chul Lee | - |
dc.contributor.affiliatedAuthor | Kyung Chan Park | - |
dc.contributor.affiliatedAuthor | Young Il Yeom | - |
dc.contributor.alternativeName | 정유리 | - |
dc.contributor.alternativeName | 장예진 | - |
dc.contributor.alternativeName | 강민호 | - |
dc.contributor.alternativeName | 박영수 | - |
dc.contributor.alternativeName | 오수진 | - |
dc.contributor.alternativeName | 이동철 | - |
dc.contributor.alternativeName | Xie | - |
dc.contributor.alternativeName | 유향숙 | - |
dc.contributor.alternativeName | 박경찬 | - |
dc.contributor.alternativeName | 염영일 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, vol. 35, no. 4, pp. 335-341 | - |
dc.identifier.doi | 10.1007/s10059-013-2319-4 | - |
dc.subject.keyword | glycolysis | - |
dc.subject.keyword | glycolysis-dependent | - |
dc.subject.keyword | lactate | - |
dc.subject.keyword | PKM2 | - |
dc.subject.keyword | SLC16A3 | - |
dc.subject.local | glycolysis | - |
dc.subject.local | Glycolysis | - |
dc.subject.local | glycolysis-dependent | - |
dc.subject.local | Lactate | - |
dc.subject.local | lactate | - |
dc.subject.local | PKM2 | - |
dc.subject.local | SLC16A3 | - |
dc.description.journalClass | Y | - |
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