A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis

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A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis
Seong-Min Park; S J Park; Hee Jin Kim; Oh Hyung Kwon; T W Kang; Hyun Ahm Sohn; Seon-Kyu Kim; S M Noh; K S Song; S J Jang; Yong Sung Kim; Seon-Young Kim
Bibliographic Citation
Experimental and Molecular Medicine, vol. 45, pp. e31-e31
Publication Year
Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput RNA sequencing (RNA-seq). Several of the lincRNAs identified have been well characterized for their functions in carcinogenesis. Here we performed RNA-seq experiments comparing gastric cancer with normal tissues to find differentially expressed transcripts in intergenic regions. By analyzing our own RNA-seq and public microarray data, we identified 31 transcripts, including a known expressed sequence tag, BM742401. BM742401 was downregulated in cancer, and its downregulation was associated with poor survival in gastric cancer patients. Ectopic overexpression of BM742401 inhibited metastasis-related phenotypes and decreased the concentration of extracellular MMP9. These results suggest that BM742401 is a potential lincRNA marker and therapeutic target.
Gastric cancerHigh-throughput RNA sequencingLong intergenic non-coding RNANon-coding RNARNA-seq
Springer-Nature Pub Group
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Aging Convergence Research Center > 1. Journal Articles
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