DC Field | Value | Language |
---|---|---|
dc.contributor.author | Y J Kim | - |
dc.contributor.author | Ho Bum Kang | - |
dc.contributor.author | H S Yim | - |
dc.contributor.author | J H Kim | - |
dc.contributor.author | Jae Wha Kim | - |
dc.date.accessioned | 2017-04-19T09:41:51Z | - |
dc.date.available | 2017-04-19T09:41:51Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | 10.3892/or.2013.2642 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11456 | - |
dc.description.abstract | To discover the molecular mechanism of N-Myc downstream-regulated gene 2 (NDRG2), a newly found differentiation-related tumor suppressor, the relationships between NDRG2 and E-cadherin were investigated in tumor cells and tissues. Positive correlations between the expression of E-cadherin and NDRG2 were shown in several colon cancer cell lines as well as in colon cancer tissues. According to the transcription assays using a reporter plasmid containing E-cadherin promoter region (-368~+51), NDRG2 introduction into colon cancer cell lines induced upregulation of E-cadherin promoter activity and its transcription. On the contrary, inhibition of NDRG2 expression by siRNA treatment caused the decrease of E-cadherin transcription. Snail, a zinc-finger transcriptional repressor, was shown to be a mediator of NDRG2-regulated E-cadherin expression. The enhancement of glycogen synthase kinase 3β (GSK-3β) activity by NDRG2 overexpression caused proteasomal degradation of Snail transcription factor followed by transcriptional de-repression of E-cadherin. We also found that NDRG2 could mediate cell density-regulated E-cadherin expression. The increase of NDRG2 expression with cell density preceded E-cadherin expression, and the regulation of Snail activity by GSK-3β was also related to this process. | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients | - |
dc.title.alternative | NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients | - |
dc.type | Article | - |
dc.citation.title | Oncology Reports | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 1898 | - |
dc.citation.startPage | 1890 | - |
dc.citation.volume | 30 | - |
dc.contributor.affiliatedAuthor | Ho Bum Kang | - |
dc.contributor.affiliatedAuthor | Jae Wha Kim | - |
dc.contributor.alternativeName | 김영준 | - |
dc.contributor.alternativeName | 강호범 | - |
dc.contributor.alternativeName | 임현선 | - |
dc.contributor.alternativeName | 김주헌 | - |
dc.contributor.alternativeName | 김재화 | - |
dc.identifier.bibliographicCitation | Oncology Reports, vol. 30, no. 4, pp. 1890-1898 | - |
dc.identifier.doi | 10.3892/or.2013.2642 | - |
dc.subject.keyword | E-cadherin | - |
dc.subject.keyword | Epithelial-mesenchymal transition | - |
dc.subject.keyword | Glycogen synthase kinase 3β phosphorylation | - |
dc.subject.keyword | N-Myc downstream-regulated gene 2 | - |
dc.subject.keyword | Snail | - |
dc.subject.local | E-cadherin | - |
dc.subject.local | Epithelial-mesenchymal transition | - |
dc.subject.local | Epithelial-mesenchymal transition (EMT) | - |
dc.subject.local | Epithelialmesenchymal transition | - |
dc.subject.local | epithelial-mesenchymal transition | - |
dc.subject.local | Epithelial.mesenchymal transition | - |
dc.subject.local | Glycogen synthase kinase 3β phosphorylation | - |
dc.subject.local | N-myc downstream regulated gene 2 | - |
dc.subject.local | N-Myc downstream-regulated gene 2 | - |
dc.subject.local | snail | - |
dc.subject.local | Snail | - |
dc.description.journalClass | Y | - |
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