NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients

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dc.contributor.authorY J Kim-
dc.contributor.authorHo Bum Kang-
dc.contributor.authorH S Yim-
dc.contributor.authorJ H Kim-
dc.contributor.authorJae Wha Kim-
dc.date.accessioned2017-04-19T09:41:51Z-
dc.date.available2017-04-19T09:41:51Z-
dc.date.issued2013-
dc.identifier.issn1021-335X-
dc.identifier.uri10.3892/or.2013.2642ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11456-
dc.description.abstractTo discover the molecular mechanism of N-Myc downstream-regulated gene 2 (NDRG2), a newly found differentiation-related tumor suppressor, the relationships between NDRG2 and E-cadherin were investigated in tumor cells and tissues. Positive correlations between the expression of E-cadherin and NDRG2 were shown in several colon cancer cell lines as well as in colon cancer tissues. According to the transcription assays using a reporter plasmid containing E-cadherin promoter region (-368~+51), NDRG2 introduction into colon cancer cell lines induced upregulation of E-cadherin promoter activity and its transcription. On the contrary, inhibition of NDRG2 expression by siRNA treatment caused the decrease of E-cadherin transcription. Snail, a zinc-finger transcriptional repressor, was shown to be a mediator of NDRG2-regulated E-cadherin expression. The enhancement of glycogen synthase kinase 3β (GSK-3β) activity by NDRG2 overexpression caused proteasomal degradation of Snail transcription factor followed by transcriptional de-repression of E-cadherin. We also found that NDRG2 could mediate cell density-regulated E-cadherin expression. The increase of NDRG2 expression with cell density preceded E-cadherin expression, and the regulation of Snail activity by GSK-3β was also related to this process.-
dc.publisherSpandidos Publ Ltd-
dc.titleNDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients-
dc.title.alternativeNDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients-
dc.typeArticle-
dc.citation.titleOncology Reports-
dc.citation.number4-
dc.citation.endPage1898-
dc.citation.startPage1890-
dc.citation.volume30-
dc.contributor.affiliatedAuthorHo Bum Kang-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.alternativeName김영준-
dc.contributor.alternativeName강호범-
dc.contributor.alternativeName임현선-
dc.contributor.alternativeName김주헌-
dc.contributor.alternativeName김재화-
dc.identifier.bibliographicCitationOncology Reports, vol. 30, no. 4, pp. 1890-1898-
dc.identifier.doi10.3892/or.2013.2642-
dc.subject.keywordE-cadherin-
dc.subject.keywordEpithelial-mesenchymal transition-
dc.subject.keywordGlycogen synthase kinase 3β phosphorylation-
dc.subject.keywordN-Myc downstream-regulated gene 2-
dc.subject.keywordSnail-
dc.subject.localE-cadherin-
dc.subject.localEpithelial-mesenchymal transition-
dc.subject.localEpithelial-mesenchymal transition (EMT)-
dc.subject.localEpithelialmesenchymal transition-
dc.subject.localepithelial-mesenchymal transition-
dc.subject.localEpithelial.mesenchymal transition-
dc.subject.localGlycogen synthase kinase 3β phosphorylation-
dc.subject.localN-myc downstream regulated gene 2-
dc.subject.localN-Myc downstream-regulated gene 2-
dc.subject.localsnail-
dc.subject.localSnail-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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