Anti-allergic flavones from Arthraxon hispidus = 아스락손 히스피두스의 항알러지 플라본

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Title
Anti-allergic flavones from Arthraxon hispidus = 아스락손 히스피두스의 항알러지 플라본
Author(s)
G H Quan; H S Chae; Hyuk Hwan Song; Kyung Seop Ahn; Hyeong Kyu Lee; Y H Kim; Sei-Ryang Oh; Y W Chin
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 61, no. 9, pp. 920-926
Publication Year
2013
Abstract
Bioactivity-guided fractionation for an EtOAc-soluble fraction of methanolic extract of Arthraxon hispidus, using primary cell assay with bone marrow-derived mast cells (BMMC), led to an isolation of six new flavones and nine known compounds. The structures of the new compounds were established by one dimensional (ID)- and 2D-NMR spectroscopic data, as luteolin 8-C-β-kerriopyranoside (1), luteolin 8-acetic acid methyl ester (2), 7-methyl-luteolin 8-C-β-(6-deoxyxylo-3-uloside) (3), apigenin 8-C-α-fucopyranoside (4), apigenin 8-C-β-fucopyranoside (5) and luteolin 8-C-β-fucopyranoside (6). All the isolates were evaluated for inhibitory activities on interleukin-6 release in the primary cultures using BMMC. Of the tested compounds, compounds 2, 3 and 10 were found to inhibit interleukin-6 release. Furthermore, compound 2 displayed inhibitory activity against prostaglandin D2, leukotriene C4, and β-hexosaminidase releases.
Keyword
Arthraxon hispidusflavonoidbone-marrow derived mast cellinterleukin-6leukotriene C4prostaglandin D2
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.c13-00239
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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