Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sunghyun Kang | - |
| dc.contributor.author | Hye-Jin Min | - |
| dc.contributor.author | M S Kang | - |
| dc.contributor.author | M G Jung | - |
| dc.contributor.author | Semi Kim | - |
| dc.date.accessioned | 2017-04-19T09:41:58Z | - |
| dc.date.available | 2017-04-19T09:41:58Z | - |
| dc.date.issued | 2013 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | 10.1016/j.bmcl.2013.01.055 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11470 | - |
| dc.description.abstract | TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4. | - |
| dc.publisher | Elsevier | - |
| dc.title | Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors | - |
| dc.title.alternative | Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
| dc.citation.number | 6 | - |
| dc.citation.endPage | 1751 | - |
| dc.citation.startPage | 1748 | - |
| dc.citation.volume | 23 | - |
| dc.contributor.affiliatedAuthor | Sunghyun Kang | - |
| dc.contributor.affiliatedAuthor | Semi Kim | - |
| dc.contributor.alternativeName | 강성현 | - |
| dc.contributor.alternativeName | 민혜진 | - |
| dc.contributor.alternativeName | 강민서 | - |
| dc.contributor.alternativeName | 정명근 | - |
| dc.contributor.alternativeName | 김세미 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 6, pp. 1748-1751 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2013.01.055 | - |
| dc.subject.keyword | 2-Hydroxydiarylamide | - |
| dc.subject.keyword | Antitumor | - |
| dc.subject.keyword | Invasion | - |
| dc.subject.keyword | TMPRSS4 inhibitors | - |
| dc.subject.local | 2-Hydroxydiarylamide | - |
| dc.subject.local | Anti-tumor | - |
| dc.subject.local | antitumor | - |
| dc.subject.local | Antitumor | - |
| dc.subject.local | invasion | - |
| dc.subject.local | Invasion | - |
| dc.subject.local | TMPRSS4 inhibitors | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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