Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1

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dc.contributor.authorD W Kim-
dc.contributor.authorS M Ko-
dc.contributor.authorYoung Joo Jeon-
dc.contributor.authorY W Noh-
dc.contributor.authorN J Choi-
dc.contributor.authorS D Cho-
dc.contributor.authorH S Moon-
dc.contributor.authorY S Cho-
dc.contributor.authorJ C Shin-
dc.contributor.authorS M Park-
dc.contributor.authorK S Seo-
dc.contributor.authorJi Young Choi-
dc.contributor.authorJ I Chae-
dc.contributor.authorJ H Shim-
dc.date.accessioned2017-04-19T09:42:03Z-
dc.date.available2017-04-19T09:42:03Z-
dc.date.issued2013-
dc.identifier.issn1019-6439-
dc.identifier.uri10.3892/ijo.2013.2028ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11474-
dc.description.abstractHonokiol (HK), a novel plant-derived natural product, is a physiologically activated compound with polyphenolic structure, and has been identified to function as an anticancer agent. It has been widely used in several diseases as a traditional medicine for a long time. We investigated whether HK could show anticancer effects on two oral squamous cell lines (OSCCs), HN-22 and HSC-4. We demonstrated that HK-treated cells showed dramatic reduction in cell growth and apoptotic cell morphologies. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly inhibited by HK in a dose-dependent manner. Furthermore, we checked changes in cell cycle regulatory proteins and anti-apoptotic proteins at the molecular level, which are known as Sp1 target genes. The important key regulators in the cell cycle such as p27 and p21 were up-regulated by HK-mediated down-regulation of Sp1, whereas anti-apoptotic proteins including Mcl-1 and survivin were decreased, resulting in caspase-dependent apoptosis. Taken together, results from this study suggest that HK could modulate Sp1 transactivation and induce apoptotic cell death through the regulation of cell cycle and suppression of anti apoptotic proteins. In addition, HK may be used in cancer prevention and therapies to improve the clinical outcome as an anticancer drug.-
dc.publisherSpandidos Publ Ltd-
dc.titleAnti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1-
dc.title.alternativeAnti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1-
dc.typeArticle-
dc.citation.titleInternational Journal of Oncology-
dc.citation.number4-
dc.citation.endPage1110-
dc.citation.startPage1103-
dc.citation.volume43-
dc.contributor.affiliatedAuthorYoung Joo Jeon-
dc.contributor.affiliatedAuthorJi Young Choi-
dc.contributor.alternativeName김동욱-
dc.contributor.alternativeName고선미-
dc.contributor.alternativeName전영주-
dc.contributor.alternativeName노영욱-
dc.contributor.alternativeName최낙진-
dc.contributor.alternativeName조성대-
dc.contributor.alternativeName문홍섭-
dc.contributor.alternativeName조영식-
dc.contributor.alternativeName신재천-
dc.contributor.alternativeName박선민-
dc.contributor.alternativeName서강석-
dc.contributor.alternativeName최지영-
dc.contributor.alternativeName채정일-
dc.contributor.alternativeName심정현-
dc.identifier.bibliographicCitationInternational Journal of Oncology, vol. 43, no. 4, pp. 1103-1110-
dc.identifier.doi10.3892/ijo.2013.2028-
dc.subject.keywordApoptosis-
dc.subject.keywordHonokiol-
dc.subject.keywordOral squamous cancer cell-
dc.subject.keywordSpecificity protein 1-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localhonokiol-
dc.subject.localHonokiol-
dc.subject.localOral squamous cancer cell-
dc.subject.localSpecificity protein-1-
dc.subject.localSpecificity protein 1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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