Enhanced antioxidant and protective activities on retinal ganglion cells of carotenoids-overexpressing transgenic carrot

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Title
Enhanced antioxidant and protective activities on retinal ganglion cells of carotenoids-overexpressing transgenic carrot
Author(s)
K D Yoon; S N Kang; J Y Bae; Haeng Soon Lee; Sang Soo Kwak; I Jang; I S Kim; C H Lee; J M Bae; S W Lee; M J Ahn
Bibliographic Citation
Current Drug Targets, vol. 14, no. 9, pp. 999-1005
Publication Year
2013
Abstract
Carotenoids are considered to act as antioxidants and protect humans from serious disorders such as skin degeneration and ageing, cardiovascular disease, certain types of cancer, and age-related diseases of the eye. In this study, these chemopreventive activities of a carotenoids-overexpressing transgenic carrot were evaluated. The results of DPPH, hydroxyl, and superoxide radical scavenging tests demonstrate that the acetone extract obtained from the taproots of the carrot plants exhibits significant antioxidant activity. A higher activity was detected in the transgenic carrot extract compared with the wild-type extract. A chemopreventive activity test for degenerative diseases of the eye revealed that pretreatment with the carrot extract reduced cell death in a retinal ganglion cell line, RGC-5 cells exposed to 1-buthionine- (R,S)-sulfoximine and L-glutamic acid.
Keyword
Antioxidant activityCarotenoidsRGC-5 cellsTransgenic carrot
ISSN
1389-4501
Publisher
Bentham Science Publ Ltd
DOI
http://dx.doi.org/10.2174/1389450111314090008
Type
Article
Appears in Collections:
Division of Biomaterials Research > Plant Systems Engineering Research > 1. Journal Articles
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