DC Field | Value | Language |
---|---|---|
dc.contributor.author | A A Shah | - |
dc.contributor.author | C Wang | - |
dc.contributor.author | S H Yoon | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | Eui Sung Choi | - |
dc.contributor.author | S W Kim | - |
dc.date.accessioned | 2017-04-19T09:42:44Z | - |
dc.date.available | 2017-04-19T09:42:44Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0168-1656 | - |
dc.identifier.uri | 10.1016/j.jbiotec.2013.07.023 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11497 | - |
dc.description.abstract | Geraniol is an important industrial material and a potential candidate of advanced biofuels. One challenge of microbial geraniol production is the toxicity to hosts. However, the poor understanding on geraniol tolerance mechanism is an obstacle for developing geraniol tolerant host. This study genome-widely screened a shot-gun DNA library of Escherichia coli and found that recA is able to confer geraniol tolerance in E. coli. The recA knockout mutant was found extremely sensitive to geraniol. Based on our data, it was deciphered that recA provided tolerance through SOS response network responding to DNA damage caused by geraniol. RecA-mediated SOS response activates the homologous recombinational repair by RecB and RecN for corrective DNA maintenance. This protection mechanism suggests an effective strategy to combat geraniol toxicity in E. coli. | - |
dc.publisher | Elsevier | - |
dc.title | RecA-mediated SOS response provides a geraniol tolerance in Escherichia coli | - |
dc.title.alternative | RecA-mediated SOS response provides a geraniol tolerance in Escherichia coli | - |
dc.type | Article | - |
dc.citation.title | Journal of Biotechnology | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 364 | - |
dc.citation.startPage | 357 | - |
dc.citation.volume | 167 | - |
dc.contributor.affiliatedAuthor | Eui Sung Choi | - |
dc.contributor.alternativeName | Shah | - |
dc.contributor.alternativeName | Wang | - |
dc.contributor.alternativeName | 윤상활 | - |
dc.contributor.alternativeName | 김재연 | - |
dc.contributor.alternativeName | 최의성 | - |
dc.contributor.alternativeName | 김선원 | - |
dc.identifier.bibliographicCitation | Journal of Biotechnology, vol. 167, no. 4, pp. 357-364 | - |
dc.identifier.doi | 10.1016/j.jbiotec.2013.07.023 | - |
dc.subject.keyword | DNA repair | - |
dc.subject.keyword | Escherichia coli | - |
dc.subject.keyword | Geraniol | - |
dc.subject.keyword | RecA | - |
dc.subject.keyword | SOS response | - |
dc.subject.keyword | Stress tolerance | - |
dc.subject.local | DNA repair | - |
dc.subject.local | Escherichia coli. | - |
dc.subject.local | escherichia coli | - |
dc.subject.local | Escherichia Coli | - |
dc.subject.local | Escherichia coli | - |
dc.subject.local | E.coli | - |
dc.subject.local | escherichia coil | - |
dc.subject.local | E. coli | - |
dc.subject.local | E. Coli | - |
dc.subject.local | Geraniol | - |
dc.subject.local | RecA | - |
dc.subject.local | SOS response | - |
dc.subject.local | stress tolerance | - |
dc.subject.local | Stress tolerance | - |
dc.description.journalClass | Y | - |
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