RecA-mediated SOS response provides a geraniol tolerance in Escherichia coli

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dc.contributor.authorA A Shah-
dc.contributor.authorC Wang-
dc.contributor.authorS H Yoon-
dc.contributor.authorJ Y Kim-
dc.contributor.authorEui Sung Choi-
dc.contributor.authorS W Kim-
dc.date.accessioned2017-04-19T09:42:44Z-
dc.date.available2017-04-19T09:42:44Z-
dc.date.issued2013-
dc.identifier.issn0168-1656-
dc.identifier.uri10.1016/j.jbiotec.2013.07.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11497-
dc.description.abstractGeraniol is an important industrial material and a potential candidate of advanced biofuels. One challenge of microbial geraniol production is the toxicity to hosts. However, the poor understanding on geraniol tolerance mechanism is an obstacle for developing geraniol tolerant host. This study genome-widely screened a shot-gun DNA library of Escherichia coli and found that recA is able to confer geraniol tolerance in E. coli. The recA knockout mutant was found extremely sensitive to geraniol. Based on our data, it was deciphered that recA provided tolerance through SOS response network responding to DNA damage caused by geraniol. RecA-mediated SOS response activates the homologous recombinational repair by RecB and RecN for corrective DNA maintenance. This protection mechanism suggests an effective strategy to combat geraniol toxicity in E. coli.-
dc.publisherElsevier-
dc.titleRecA-mediated SOS response provides a geraniol tolerance in Escherichia coli-
dc.title.alternativeRecA-mediated SOS response provides a geraniol tolerance in Escherichia coli-
dc.typeArticle-
dc.citation.titleJournal of Biotechnology-
dc.citation.number4-
dc.citation.endPage364-
dc.citation.startPage357-
dc.citation.volume167-
dc.contributor.affiliatedAuthorEui Sung Choi-
dc.contributor.alternativeNameShah-
dc.contributor.alternativeNameWang-
dc.contributor.alternativeName윤상활-
dc.contributor.alternativeName김재연-
dc.contributor.alternativeName최의성-
dc.contributor.alternativeName김선원-
dc.identifier.bibliographicCitationJournal of Biotechnology, vol. 167, no. 4, pp. 357-364-
dc.identifier.doi10.1016/j.jbiotec.2013.07.023-
dc.subject.keywordDNA repair-
dc.subject.keywordEscherichia coli-
dc.subject.keywordGeraniol-
dc.subject.keywordRecA-
dc.subject.keywordSOS response-
dc.subject.keywordStress tolerance-
dc.subject.localDNA repair-
dc.subject.localEscherichia coli.-
dc.subject.localescherichia coli-
dc.subject.localEscherichia Coli-
dc.subject.localEscherichia coli-
dc.subject.localE.coli-
dc.subject.localescherichia coil-
dc.subject.localE. coli-
dc.subject.localE. Coli-
dc.subject.localGeraniol-
dc.subject.localRecA-
dc.subject.localSOS response-
dc.subject.localstress tolerance-
dc.subject.localStress tolerance-
dc.description.journalClassY-
Appears in Collections:
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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