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Open Access@KRIBBOchang Branch InstituteChemical Biology Research Center1. Journal Articles

A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases

Cited 41 time in scopus
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dc.contributor.authorH Liu-
dc.contributor.authorK Liu-
dc.contributor.authorZ Huang-
dc.contributor.authorChan-Mi Park-
dc.contributor.authorN R Thimmegowda-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorInJa Ryoo-
dc.contributor.authorL He-
dc.contributor.authorSun Ok Kim-
dc.contributor.authorN Oi-
dc.contributor.authorK W Lee-
dc.contributor.authorNak Kyun Soung-
dc.contributor.authorA M Bode-
dc.contributor.authorY Yang-
dc.contributor.authorX Zhou-
dc.contributor.authorR L Erikson-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorJoonsung Hwang-
dc.contributor.authorK E Kim-
dc.contributor.authorZ Dong-
dc.contributor.authorBo Yeon Kim-
dc.date.accessioned2017-04-19T09:42:46Z-
dc.date.available2017-04-19T09:42:46Z-
dc.date.issued2013-
dc.identifier.issn0021-9258-
dc.identifier.uri10.1074/jbc.M113.464669ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11512-
dc.description.abstractBackground: Binding to the ATP site results in poor selectivity; therefore, development of ATP-noncompetitive inhibitors is needed. Results: A modified chrysin with anticancer activity targets Cdks and binds to a Cdk2 allosteric site, not the ATP pocket. Conclusion: Modified chrysin is a novel ATP-noncompetitive inhibitor. Significance: This pharmacophore model might provide insights for the development of new ATP-noncompetitive agents-
dc.publisherAmer Soc Biochemistry Molecular Biology Inc-
dc.titleA chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases-
dc.title.alternativeA chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases-
dc.typeArticle-
dc.citation.titleJournal of Biological Chemistry-
dc.citation.number36-
dc.citation.endPage25937-
dc.citation.startPage25924-
dc.citation.volume288-
dc.contributor.affiliatedAuthorChan-Mi Park-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorInJa Ryoo-
dc.contributor.affiliatedAuthorSun Ok Kim-
dc.contributor.affiliatedAuthorNak Kyun Soung-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorJoonsung Hwang-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.alternativeNameLiu-
dc.contributor.alternativeNameLiu-
dc.contributor.alternativeNameHuang-
dc.contributor.alternativeName박찬미-
dc.contributor.alternativeNameThimmegowda-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeNameHe-
dc.contributor.alternativeName김선옥-
dc.contributor.alternativeNameOi-
dc.contributor.alternativeName이기원-
dc.contributor.alternativeName성낙균-
dc.contributor.alternativeNameBode-
dc.contributor.alternativeNameYang-
dc.contributor.alternativeNameZhou-
dc.contributor.alternativeNameErikson-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName황준성-
dc.contributor.alternativeName김균언-
dc.contributor.alternativeNameDong-
dc.contributor.alternativeName김보연-
dc.identifier.bibliographicCitationJournal of Biological Chemistry, vol. 288, no. 36, pp. 25924-25937-
dc.identifier.doi10.1074/jbc.M113.464669-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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