Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway = LGR5에 의한 G12/13-Rho 신호전달계의 활성화

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dc.contributor.authorMi-So Kwon-
dc.contributor.authorBioh Park-
dc.contributor.authorH M Kim-
dc.contributor.authorSunhong Kim-
dc.date.accessioned2017-04-19T09:42:46Z-
dc.date.available2017-04-19T09:42:46Z-
dc.date.issued2013-
dc.identifier.issn1016-8478-
dc.identifier.uri10.1007/s10059-013-0173-zko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11514-
dc.description.abstractLeucine-rich repeat-containing G-protein coupled receptor 5 (LGR5/GPR49) is highly expressed in adult stem cells of various tissues, such as intestine, hair follicles, and stomach. LGR5 is also overexpressed in some colon and ovarian tumors. Recent reports show that R-spondin (RSPO) family ligands bind to and activate LGR5, enhancing canonical Wnt signaling via the interaction with LRP5/6 and Frizzled. The identity of heterotrimeric G-proteins coupled to LGR5, however, remains unclear. Here, we show that Rho GTPase is a downstream target of LGR5. Overexpression of LGR5 induced SRF-RE luciferase activity, a reporter of Rho signaling. RSPOs, ligands for LGR4, LGR5, and LGR6, however, did not induce SRF-RE reporter activity in the presence of LGR5. Consistently, LGR5-induced activity of the SRF-RE reporter was inhibited by Rho inhibitor C3 transferase and RhoA N19 mutant, and knockdown of Gα12/13 genes blocked the reporter activity induced by LGR5. In addition, focal adhesion kinase, NF-κB and c-fos, targets of Rho GTPase, were shown to be regulated by LGR5. Here, we have demonstrated, for the first time, that LGR5 is coupled to the Rho pathway through G12/13 signaling.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleLeucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway = LGR5에 의한 G12/13-Rho 신호전달계의 활성화-
dc.title.alternativeLeucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number3-
dc.citation.endPage272-
dc.citation.startPage267-
dc.citation.volume36-
dc.contributor.affiliatedAuthorMi-So Kwon-
dc.contributor.affiliatedAuthorBioh Park-
dc.contributor.affiliatedAuthorSunhong Kim-
dc.contributor.alternativeName권미소-
dc.contributor.alternativeName박비오-
dc.contributor.alternativeName김호민-
dc.contributor.alternativeName김선홍-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 36, no. 3, pp. 267-272-
dc.identifier.doi10.1007/s10059-013-0173-z-
dc.subject.keywordFAK-
dc.subject.keywordLGR5-
dc.subject.keywordNFkappaB-
dc.subject.keywordRho-
dc.subject.localFAK-
dc.subject.localLGR5-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localRho-
dc.description.journalClassY-
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