DC Field | Value | Language |
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dc.contributor.author | Mi-So Kwon | - |
dc.contributor.author | Bioh Park | - |
dc.contributor.author | H M Kim | - |
dc.contributor.author | Sunhong Kim | - |
dc.date.accessioned | 2017-04-19T09:42:46Z | - |
dc.date.available | 2017-04-19T09:42:46Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | 10.1007/s10059-013-0173-z | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11514 | - |
dc.description.abstract | Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5/GPR49) is highly expressed in adult stem cells of various tissues, such as intestine, hair follicles, and stomach. LGR5 is also overexpressed in some colon and ovarian tumors. Recent reports show that R-spondin (RSPO) family ligands bind to and activate LGR5, enhancing canonical Wnt signaling via the interaction with LRP5/6 and Frizzled. The identity of heterotrimeric G-proteins coupled to LGR5, however, remains unclear. Here, we show that Rho GTPase is a downstream target of LGR5. Overexpression of LGR5 induced SRF-RE luciferase activity, a reporter of Rho signaling. RSPOs, ligands for LGR4, LGR5, and LGR6, however, did not induce SRF-RE reporter activity in the presence of LGR5. Consistently, LGR5-induced activity of the SRF-RE reporter was inhibited by Rho inhibitor C3 transferase and RhoA N19 mutant, and knockdown of Gα12/13 genes blocked the reporter activity induced by LGR5. In addition, focal adhesion kinase, NF-κB and c-fos, targets of Rho GTPase, were shown to be regulated by LGR5. Here, we have demonstrated, for the first time, that LGR5 is coupled to the Rho pathway through G12/13 signaling. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway = LGR5에 의한 G12/13-Rho 신호전달계의 활성화 | - |
dc.title.alternative | Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway | - |
dc.type | Article | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 272 | - |
dc.citation.startPage | 267 | - |
dc.citation.volume | 36 | - |
dc.contributor.affiliatedAuthor | Mi-So Kwon | - |
dc.contributor.affiliatedAuthor | Bioh Park | - |
dc.contributor.affiliatedAuthor | Sunhong Kim | - |
dc.contributor.alternativeName | 권미소 | - |
dc.contributor.alternativeName | 박비오 | - |
dc.contributor.alternativeName | 김호민 | - |
dc.contributor.alternativeName | 김선홍 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, vol. 36, no. 3, pp. 267-272 | - |
dc.identifier.doi | 10.1007/s10059-013-0173-z | - |
dc.subject.keyword | FAK | - |
dc.subject.keyword | LGR5 | - |
dc.subject.keyword | NFkappaB | - |
dc.subject.keyword | Rho | - |
dc.subject.local | FAK | - |
dc.subject.local | LGR5 | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Rho | - |
dc.description.journalClass | Y | - |
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