Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes

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Title
Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes
Author(s)
K Lee; Hyun Seung Ban; R Naik; Ye Seul Hong; S Son; Bo Kyung Kim; Y Xia; K B Song; H S Lee; Mi Sun Won
Bibliographic Citation
Angewandte Chemie-International Edition, vol. 52, no. 39, pp. 10286-10289
Publication Year
2013
Abstract
Tracking the target: To identify a protein that binds directly to the HIF-1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable tag and/or a photoactivatable moiety. LW6 was found to be localized to the mitochondria (see picture) and MDH2 was identified as a target protein of LW6. These results indicate that the HIF-1α inhibitory activity of LW6 is a consequence of MDH2 suppression.
Keyword
click chemistryfluorescent probesHIF inhibitorsmalate dehydrogenase 2photoaffinity labeling
ISSN
1433-7851
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/anie.201304987
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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