Open Access@KRIBBDivision of A.I. & Biomedical ResearchBiotherapeutics Translational Research Center1. Journal Articles
Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes
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- Title
- Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes
- Author(s)
- K Lee; Hyun Seung Ban; R Naik; Ye Seul Hong; S Son; Bo Kyung Kim; Y Xia; K B Song; H S Lee; Mi Sun Won
- Bibliographic Citation
- Angewandte Chemie-International Edition, vol. 52, no. 39, pp. 10286-10289
- Publication Year
- 2013
- Abstract
- Tracking the target: To identify a protein that binds directly to the HIF-1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable tag and/or a photoactivatable moiety. LW6 was found to be localized to the mitochondria (see picture) and MDH2 was identified as a target protein of LW6. These results indicate that the HIF-1α inhibitory activity of LW6 is a consequence of MDH2 suppression.
- ISSN
- 1433-7851
- Publisher
- Wiley
- Full Text Link
- http://dx.doi.org/10.1002/anie.201304987
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of A.I. & Biomedical Research > Genomic Medicine Research Center > 1. Journal Articles
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