The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 and Bcl-2-associated athanogene domain 3 expression by blocking heat shock factor 1 binding to promoters = HSF1 promoter 결합 저해로 HSP70과 BAG3 억제

Abstract

Background:HSF1 is a transcription factor that enhances cancer formation and progression. Results:Cantharidin inhibited the binding of HSF1 to theHSP70promoter and subsequently blocked HSF1-dependentHSP70 expression. Conclusion:The HSF1-dependent expression of HSP70 and BAG3 is inhibited by cantharidin, causing the down-regulation of antiapoptotic BCL-2 family proteins, especially MCL-1. Significance:This information provides a new target molecule and pathway of cantharidin.