The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 and Bcl-2-associated athanogene domain 3 expression by blocking heat shock factor 1 binding to promoters = HSF1 promoter 결합 저해로 HSP70과 BAG3 억제

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dc.contributor.authorJoo Ae Kim-
dc.contributor.authorYoungmi Kim-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorDong Cho Han-
dc.date.accessioned2017-04-19T09:43:25Z-
dc.date.available2017-04-19T09:43:25Z-
dc.date.issued2013-
dc.identifier.issn00219258-
dc.identifier.uri10.1074/jbc.M113.488346ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11535-
dc.description.abstractBackground:HSF1 is a transcription factor that enhances cancer formation and progression. Results:Cantharidin inhibited the binding of HSF1 to theHSP70promoter and subsequently blocked HSF1-dependentHSP70 expression. Conclusion:The HSF1-dependent expression of HSP70 and BAG3 is inhibited by cantharidin, causing the down-regulation of antiapoptotic BCL-2 family proteins, especially MCL-1. Significance:This information provides a new target molecule and pathway of cantharidin.-
dc.publisherAmer Soc Biochemistry Molecular Biology Inc-
dc.titleThe natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 and Bcl-2-associated athanogene domain 3 expression by blocking heat shock factor 1 binding to promoters = HSF1 promoter 결합 저해로 HSP70과 BAG3 억제-
dc.title.alternativeThe natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 and Bcl-2-associated athanogene domain 3 expression by blocking heat shock factor 1 binding to promoters-
dc.typeArticle-
dc.citation.titleJournal of Biological Chemistry-
dc.citation.number40-
dc.citation.endPage28726-
dc.citation.startPage28713-
dc.citation.volume288-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.alternativeName김주애-
dc.contributor.alternativeName김영미-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName한동초-
dc.identifier.bibliographicCitationJournal of Biological Chemistry, vol. 288, no. 40, pp. 28713-28726-
dc.identifier.doi10.1074/jbc.M113.488346-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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