DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young-Jun Park | - |
dc.contributor.author | Sung Jin Yoon | - |
dc.contributor.author | Hyun Woo Suh | - |
dc.contributor.author | Dongoh Kim | - |
dc.contributor.author | J R Park | - |
dc.contributor.author | Haiyoung Jung | - |
dc.contributor.author | Tae-Don Kim | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | Jeong Ki Min | - |
dc.contributor.author | Hee-Jun Na | - |
dc.contributor.author | Seon-Jin Lee | - |
dc.contributor.author | Hee Gu Lee | - |
dc.contributor.author | Y H Lee | - |
dc.contributor.author | H B Lee | - |
dc.contributor.author | In Pyo Choi | - |
dc.date.accessioned | 2017-04-19T09:43:42Z | - |
dc.date.available | 2017-04-19T09:43:42Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1553-7366 | - |
dc.identifier.uri | 10.1371/journal.ppat.1003646 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11537 | - |
dc.description.abstract | Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. However, its role in the inflammatory process remains unclear. In this report, we demonstrate that Txnip-/- mice are significantly more susceptible to lipopolysaccharide (LPS)-induced endotoxic shock. In response to LPS, Txnip-/- macrophages produced significantly higher levels of nitric oxide (NO) and inducible nitric oxide synthase (iNOS), and an iNOS inhibitor rescued Txnip-/- mice from endotoxic shock-induced death, demonstrating that NO is a major factor in TXNIP-mediated endotoxic shock. This susceptibility phenotype of Txnip-/- mice occurred despite reduced IL-1β secretion due to increased S-nitrosylation of NLRP3 compared to wild-type controls. Taken together, these data demonstrate that TXNIP is a novel molecule that links NO synthesis and NLRP3 inflammasome activation during endotoxic shock. | - |
dc.publisher | Public Library of Science | - |
dc.title | TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis | - |
dc.title.alternative | TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis | - |
dc.type | Article | - |
dc.citation.title | PLoS Pathogens | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 1003646 | - |
dc.citation.startPage | 1003646 | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Young-Jun Park | - |
dc.contributor.affiliatedAuthor | Sung Jin Yoon | - |
dc.contributor.affiliatedAuthor | Hyun Woo Suh | - |
dc.contributor.affiliatedAuthor | Dongoh Kim | - |
dc.contributor.affiliatedAuthor | Haiyoung Jung | - |
dc.contributor.affiliatedAuthor | Tae-Don Kim | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | Jeong Ki Min | - |
dc.contributor.affiliatedAuthor | Hee-Jun Na | - |
dc.contributor.affiliatedAuthor | Seon-Jin Lee | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.affiliatedAuthor | In Pyo Choi | - |
dc.contributor.alternativeName | 박영준 | - |
dc.contributor.alternativeName | 윤성진 | - |
dc.contributor.alternativeName | 서현우 | - |
dc.contributor.alternativeName | 김동오 | - |
dc.contributor.alternativeName | 박정란 | - |
dc.contributor.alternativeName | 정해용 | - |
dc.contributor.alternativeName | 김태돈 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 민정기 | - |
dc.contributor.alternativeName | 나희준 | - |
dc.contributor.alternativeName | 이선진 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.contributor.alternativeName | 이영호 | - |
dc.contributor.alternativeName | 이희봉 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.identifier.bibliographicCitation | PLoS Pathogens, vol. 9, no. 10, pp. 1003646-1003646 | - |
dc.identifier.doi | 10.1371/journal.ppat.1003646 | - |
dc.description.journalClass | Y | - |
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