Combination of poly-gamma-glutamate and cyclophosphamide enhanced antitumor efficacy against tumor growth and metastasis in a melanoma model

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dc.contributor.authorDoo Jin Kim-
dc.contributor.authorEn Jin Kim-
dc.contributor.authorTae Young Lee-
dc.contributor.authorJi Na Won-
dc.contributor.authorM H Sung-
dc.contributor.authorHaryoung Poo-
dc.date.accessioned2017-04-19T09:43:42Z-
dc.date.available2017-04-19T09:43:42Z-
dc.date.issued2013-
dc.identifier.issn1017-7825-
dc.identifier.uri10.4014/jmb.1306.06071ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11538-
dc.description.abstractConventional chemotherapeutic regimens often accompany severe side effects and fail to induce complete regression of chemoresistant or relapsing metastatic cancers. The need for establishing more efficacious anticancer strategies led to the development of a combined modality treatment of chemotherapy in conjunction with immunotherapy or radiotherapy. It has been reported that poly-gamma-glutamate (γ-PGA), a natural polymer composed of glutamic acids, increases antitumor activity by activating antigen-presenting cells and natural killer (NK) cells. Here, we investigated the antitumor effect of γ-PGA in combination with cyclophosphamide in a murine melanoma model. Whereas cyclophosphamide alone directly triggered apoptosis of tumor cells in vitro, γ-PGA did not show cytotoxicity in tumor cells. Instead, it activated macrophages, as reflected by the upregulation of surface activation markers and the secretion of proinflammatory factors, such as nitric oxide and tumor necrosis factor α. When the antitumor effects were examined in a mouse model, combined treatment with cyclophosphamide and γ-PGA markedly suppressed tumor growth and metastasis. Notably, γ-PGA treatment dramatically increased the NK cell population in lung tissues, coinciding with decreased metastasis and increased survival. These data collectively suggest that γ-PGA can act as an immunotherapeutic agent that exhibits a synergistic antitumor effect in combination with conventional chemotherapy.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleCombination of poly-gamma-glutamate and cyclophosphamide enhanced antitumor efficacy against tumor growth and metastasis in a melanoma model-
dc.title.alternativeCombination of poly-gamma-glutamate and cyclophosphamide enhanced antitumor efficacy against tumor growth and metastasis in a melanoma model-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number9-
dc.citation.endPage1346-
dc.citation.startPage1339-
dc.citation.volume23-
dc.contributor.affiliatedAuthorDoo Jin Kim-
dc.contributor.affiliatedAuthorEn Jin Kim-
dc.contributor.affiliatedAuthorTae Young Lee-
dc.contributor.affiliatedAuthorHaryoung Poo-
dc.contributor.alternativeName김두진-
dc.contributor.alternativeName김은진-
dc.contributor.alternativeName이태영-
dc.contributor.alternativeName원지나-
dc.contributor.alternativeName성문희-
dc.contributor.alternativeName부하령-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 23, no. 9, pp. 1339-1346-
dc.identifier.doi10.4014/jmb.1306.06071-
dc.subject.keywordAntitumor effect-
dc.subject.keywordCyclophosphamide-
dc.subject.keywordMetastasis-
dc.subject.keywordNatural killer cells-
dc.subject.keywordPoly-gamma-glutamate-
dc.subject.localAnti-tumor effects-
dc.subject.localAntitumor effects-
dc.subject.localantitumor effect-
dc.subject.localAnti-tumor effect-
dc.subject.localantitumor effects-
dc.subject.localAntitumor effect-
dc.subject.localCyclophosphamide-
dc.subject.localmetastasis-
dc.subject.localMetastasis-
dc.subject.localNatural killer cell-
dc.subject.localNatural killer cells-
dc.subject.localnatural killer (NK) cells-
dc.subject.localnatural killer cell-
dc.subject.localPoly-gamma-glutamate-
dc.subject.localPoly-gamma glutamate-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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