New synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents

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dc.contributor.authorD Song-
dc.contributor.authorJ S Yang-
dc.contributor.authorC Oh-
dc.contributor.authorS Cui-
dc.contributor.authorBo Kyung Kim-
dc.contributor.authorMi Sun Won-
dc.contributor.authorJ I Lee-
dc.contributor.authorH M Kim-
dc.contributor.authorG Han-
dc.date.accessioned2017-04-19T09:43:46Z-
dc.date.available2017-04-19T09:43:46Z-
dc.date.issued2013-
dc.identifier.issn02235234-
dc.identifier.uri10.1016/j.ejmech.2013.09.022ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11546-
dc.description.abstractRhoB is expressed during tumor cell proliferation, survival, invasion, and metastasis. In malignant progression, the expression levels of RhoB are commonly attenuated. RhoB is known to be linked to the regulation of the PI3K/Akt survival pathways. Based on aliphatic amido-quaternary ammonium salts that induce apoptosis via up-regulation of RhoB, we synthesized novel aliphatic sulfonamido-quaternary ammonium salts. These new synthetic compounds were evaluated for their biological activities using an in vitro RhoB promoter assay in HeLa cells, and in a growth inhibition assay using human cancer cell lines including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. Compound 5b (ethyl-dimethyl-{3-[methyl-(tetradecane-1-sulfonyl)-amino]-propyl}-ammonium; iodide) was the most promising anticancer agent in the series, based upon the potency of growth inhibition and RhoB promotion. These new aliphatic sulfonamido-quaternary ammonium salts could be a valuable series for development of new anticancer chemotherapeutic agents.-
dc.publisherElsevier-
dc.titleNew synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents-
dc.title.alternativeNew synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents-
dc.typeArticle-
dc.citation.titleEuropean Journal of Medicinal Chemistry-
dc.citation.number0-
dc.citation.endPage677-
dc.citation.startPage670-
dc.citation.volume69-
dc.contributor.affiliatedAuthorBo Kyung Kim-
dc.contributor.affiliatedAuthorMi Sun Won-
dc.contributor.alternativeName송두나-
dc.contributor.alternativeName양지선-
dc.contributor.alternativeName오창목-
dc.contributor.alternativeNameCui-
dc.contributor.alternativeName김보경-
dc.contributor.alternativeName원미선-
dc.contributor.alternativeName이장익-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName한균희-
dc.identifier.bibliographicCitationEuropean Journal of Medicinal Chemistry, vol. 69, pp. 670-677-
dc.identifier.doi10.1016/j.ejmech.2013.09.022-
dc.subject.keywordAliphatic sulfonamido-quaternary ammonium salts-
dc.subject.keywordAnticancer chemotherapeutic agents-
dc.subject.keywordNSC126188-
dc.subject.keywordOpen-ring moiety of quaternary ammonium salts-
dc.subject.keywordPerifosine-
dc.subject.keywordRhoB-
dc.subject.localAliphatic sulfonamido-quaternary ammonium salts-
dc.subject.localAnticancer chemotherapeutic agents-
dc.subject.localNSC126188-
dc.subject.localOpen-ring moiety of quaternary ammonium salts-
dc.subject.localPerifosine-
dc.subject.localRhoB-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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