PTP 1B inhibitory action of a phytochemical propanoic acid, 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl)

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Title
PTP 1B inhibitory action of a phytochemical propanoic acid, 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl)
Author(s)
M Venkatachalam; G Singaravelu; K Govindaraju; Jong Seog Ahn
Bibliographic Citation
Current Science, vol. 105, no. 6, pp. 827-831
Publication Year
2013
Abstract
Bioassay-guided study of the n-butanol fraction of hydromethonolic flower extract of Cassia auriculata, propanoic acid, 2-(3-acetoxy-4,4,14-trimethylandrost- 8-en-17-yl) has demonstrated potential as a protein tyrosine phosphatase 1B (PTP 1B) inhibitor. An in vivo study using Wistar rats has demonstrated that propanoic acid exerted a hypoglycemic action when given orally. The results highlight the green chemistry approach in developing novel PTP 1B inhibitor.
Keyword
Cassia auriculataInsulin resistancePropanoic acidProtein tyrosine phosphatase
ISSN
0011-3891
Publisher
Indian Acad Sciences
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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