Distinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis

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dc.contributor.authorS J Lee-
dc.contributor.authorY N Yum-
dc.contributor.authorSangcheol Kim-
dc.contributor.authorY Kim-
dc.contributor.authorJ Lim-
dc.contributor.authorW J Lee-
dc.contributor.authorK H Koo-
dc.contributor.authorJ H Kim-
dc.contributor.authorJ E Kim-
dc.contributor.authorW S Lee-
dc.contributor.authorS Sohn-
dc.contributor.authorS N Park-
dc.contributor.authorJ H Park-
dc.contributor.authorJ Lee-
dc.contributor.authorS W Kwon-
dc.date.accessioned2017-04-19T09:43:58Z-
dc.date.available2017-04-19T09:43:58Z-
dc.date.issued2013-
dc.identifier.issn2045-2322-
dc.identifier.uri10.1038/srep02783ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11557-
dc.description.abstractA rapid and sensitive method to determine the characteristics of carcinogens is needed. In this study, we used a microarray-based genomics approach, with a short-term in vivo model, in combination with insights from statistical and mechanistic analyses to determine the characteristics of carcinogens. Carcinogens were evaluated based on the different mechanisms involved in the responses to genotoxic carcinogens and non-genotoxic carcinogens. Gene profiling was performed at two time points after treatment with six training and four test carcinogens. We mapped the DEG (differentially expressed gene)-related pathways to analyze cellular processes, and we discovered significant mechanisms that involve critical cellular components. Classification results were further supported by Comet and Micronucleus assays. Mechanistic studies based on gene expression profiling enhanced our understanding of the characteristics of different carcinogens. Moreover, the efficiency of this study was demonstrated by the short-term nature of the animal experiments that were conducted.-
dc.publisherSpringer-Nature Pub Group-
dc.titleDistinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis-
dc.title.alternativeDistinguishing between genotoxic and non-genotoxic hepatocarcinogens by gene expression profiling and bioinformatic pathway analysis-
dc.typeArticle-
dc.citation.titleScientific Reports-
dc.citation.number0-
dc.citation.endPage2783-
dc.citation.startPage2783-
dc.citation.volume3-
dc.contributor.affiliatedAuthorSangcheol Kim-
dc.contributor.alternativeName이슬지-
dc.contributor.alternativeName염영나-
dc.contributor.alternativeName김상철-
dc.contributor.alternativeName김유녕-
dc.contributor.alternativeName임조한-
dc.contributor.alternativeName이원준-
dc.contributor.alternativeName구경혜-
dc.contributor.alternativeName김주환-
dc.contributor.alternativeName김지은-
dc.contributor.alternativeName이우선-
dc.contributor.alternativeName손수정-
dc.contributor.alternativeName박순희-
dc.contributor.alternativeName박정힐-
dc.contributor.alternativeName이정미-
dc.contributor.alternativeName권성원-
dc.identifier.bibliographicCitationScientific Reports, vol. 3, pp. 2783-2783-
dc.identifier.doi10.1038/srep02783-
dc.description.journalClassY-
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