Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity

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dc.contributor.authorH Nakamurako
dc.contributor.authorY Yasuiko
dc.contributor.authorHyun Seung Banko
dc.date.accessioned2017-04-19T09:44:07Z-
dc.date.available2017-04-19T09:44:07Z-
dc.date.issued2013ko
dc.identifier.issn0022-328Xko
dc.identifier.uri10.1016/j.jorganchem.2013.04.007ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11566-
dc.description.abstractortho-Carborane and adamantane containing benzoxazoles were synthesized by intramolecular dehydration of the corresponding phenoxyacetanilides. Among the compounds synthesized, ortho-carborane containing benzoxazole 2b which has a carboxylic group on the benzoxazole ring, exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity with the IC50 value of 14.4 μM toward HeLa cell-based reporter gene assay.ko
dc.publisherElsevierko
dc.titleSynthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activityko
dc.typeArticleko
dc.citation.titleJournal of Organometallic Chemistry-
dc.citation.number0-
dc.citation.endPage194-
dc.citation.startPage189-
dc.citation.volume747-
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