DC Field | Value | Language |
---|---|---|
dc.contributor.author | Su Ui Lee | - |
dc.contributor.author | H J In | - |
dc.contributor.author | M S Kwon | - |
dc.contributor.author | Bi-oh Park | - |
dc.contributor.author | M Jo | - |
dc.contributor.author | Mun-Ock Kim | - |
dc.contributor.author | Sungchan Cho | - |
dc.contributor.author | Sangku Lee | - |
dc.contributor.author | Hyun Jun Lee | - |
dc.contributor.author | Y S Kwak | - |
dc.contributor.author | Sunhong Kim | - |
dc.date.accessioned | 2017-04-19T09:44:10Z | - |
dc.date.available | 2017-04-19T09:44:10Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | 10.1248/bpb.b13-00312 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11571 | - |
dc.description.abstract | G-protein coupled receptor 43 (GPR43) serves as a receptor for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 signaling remains unclear. Here, we show that β-arrestin 2 mediates the internalization of GPR43 by agonist. Agonism of GPR43 reduced the phosphorylation and nuclear translocation of nuclear factor-eB (NF-eB), which was relieved by short interfering RNA (siRNA) of β-arrestin 2. Subsequently, mRNA expression of proinflammatory cytokines, interleukin (IL)-6 and IL-1β, was downregulated by activation of GPR43 and knockdown of β-arrestin 2 recovered the expression of the cytokines. Taken together, these results suggest that GPR43 may be a plausible target for a variety of inflammatory diseases | - |
dc.publisher | Pharmaceutical Soc Japan | - |
dc.title | β-Arrestin 2 mediates G protein-coupled receptor 43 signals to Nuclear Factor-kappaB = 베타어레스틴 2에 의한 GPR43-NFkB 신호전달계의 조절 | - |
dc.title.alternative | β-Arrestin 2 mediates G protein-coupled receptor 43 signals to Nuclear Factor-kappaB | - |
dc.type | Article | - |
dc.citation.title | Biological & Pharmaceutical Bulletin | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 1759 | - |
dc.citation.startPage | 1754 | - |
dc.citation.volume | 36 | - |
dc.contributor.affiliatedAuthor | Su Ui Lee | - |
dc.contributor.affiliatedAuthor | Bi-oh Park | - |
dc.contributor.affiliatedAuthor | Mun-Ock Kim | - |
dc.contributor.affiliatedAuthor | Sungchan Cho | - |
dc.contributor.affiliatedAuthor | Sangku Lee | - |
dc.contributor.affiliatedAuthor | Hyun Jun Lee | - |
dc.contributor.affiliatedAuthor | Sunhong Kim | - |
dc.contributor.alternativeName | 이수의 | - |
dc.contributor.alternativeName | 인현주 | - |
dc.contributor.alternativeName | 권미소 | - |
dc.contributor.alternativeName | 박비오 | - |
dc.contributor.alternativeName | 조민미 | - |
dc.contributor.alternativeName | 김문옥 | - |
dc.contributor.alternativeName | 조성찬 | - |
dc.contributor.alternativeName | 이상구 | - |
dc.contributor.alternativeName | 이현준 | - |
dc.contributor.alternativeName | 곽영신 | - |
dc.contributor.alternativeName | 김선홍 | - |
dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 36, no. 11, pp. 1754-1759 | - |
dc.identifier.doi | 10.1248/bpb.b13-00312 | - |
dc.subject.keyword | β-arrestin | - |
dc.subject.keyword | G protein-coupled receptor 43 | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | Nuclear factor-κB | - |
dc.subject.local | β-arrestin | - |
dc.subject.local | G protein-coupled receptor 43 | - |
dc.subject.local | Inflammation | - |
dc.subject.local | inflammation | - |
dc.subject.local | nflammation | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.description.journalClass | Y | - |
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