Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g)

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Title
Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g)
Author(s)
Jong-Tae KimSeon-Jin LeeBo Yeon KimChul Ho LeeYoung Il Yeom; Yong Kyung Choe; D Y Yoon; S K Chae; J W Kim; Y Yang; J S Lim; Hee Gu Lee
Bibliographic Citation
FEBS Letters, vol. 587, no. 22, pp. 3668-3674
Publication Year
2013
Abstract
Eukaryotic translation initiation factor 3 is composed of 13 subunits (eIF3a through eIF3m) and plays an essential role in translation. During apoptosis, several caspases rapidly down-regulate protein synthesis by cleaving eIF4G, -4B, -3j, and -2α. In this study, we found that the activation of caspases by cisplatin in T24 cells induces the cleavage of subunit G of the eIF3 complex (eIF3g). The cleavage site (SLRD220G) was identified, and we found that the cleaved N-terminus was translocated to the nucleus, activating caspase-3, and that it also showed a strong DNase activity. These data demonstrate the important roles of eIF3g in the translation initiation machinery and in DNA degradation during apoptosis.
Keyword
ApoptosisCaspaseDNaseeIF3gTranslation initiation factor
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2013.09.027
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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