DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong-Tae Kim | - |
dc.contributor.author | Seon-Jin Lee | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Chul Ho Lee | - |
dc.contributor.author | Young Il Yeom | - |
dc.contributor.author | Yong Kyung Choe | - |
dc.contributor.author | D Y Yoon | - |
dc.contributor.author | S K Chae | - |
dc.contributor.author | J W Kim | - |
dc.contributor.author | Y Yang | - |
dc.contributor.author | J S Lim | - |
dc.contributor.author | Hee Gu Lee | - |
dc.date.accessioned | 2017-04-19T09:45:19Z | - |
dc.date.available | 2017-04-19T09:45:19Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | 10.1016/j.febslet.2013.09.027 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11584 | - |
dc.description.abstract | Eukaryotic translation initiation factor 3 is composed of 13 subunits (eIF3a through eIF3m) and plays an essential role in translation. During apoptosis, several caspases rapidly down-regulate protein synthesis by cleaving eIF4G, -4B, -3j, and -2α. In this study, we found that the activation of caspases by cisplatin in T24 cells induces the cleavage of subunit G of the eIF3 complex (eIF3g). The cleavage site (SLRD220G) was identified, and we found that the cleaved N-terminus was translocated to the nucleus, activating caspase-3, and that it also showed a strong DNase activity. These data demonstrate the important roles of eIF3g in the translation initiation machinery and in DNA degradation during apoptosis. | - |
dc.publisher | Wiley | - |
dc.title | Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g) | - |
dc.title.alternative | Caspase-mediated cleavage and DNase activity of the translation initiation factor 3, subunit G (eIF3g) | - |
dc.type | Article | - |
dc.citation.title | FEBS Letters | - |
dc.citation.number | 22 | - |
dc.citation.endPage | 3674 | - |
dc.citation.startPage | 3668 | - |
dc.citation.volume | 587 | - |
dc.contributor.affiliatedAuthor | Jong-Tae Kim | - |
dc.contributor.affiliatedAuthor | Seon-Jin Lee | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.affiliatedAuthor | Chul Ho Lee | - |
dc.contributor.affiliatedAuthor | Young Il Yeom | - |
dc.contributor.affiliatedAuthor | Yong Kyung Choe | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.alternativeName | 김종태 | - |
dc.contributor.alternativeName | 이선진 | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 이철호 | - |
dc.contributor.alternativeName | 염영일 | - |
dc.contributor.alternativeName | 최용경 | - |
dc.contributor.alternativeName | 윤도영 | - |
dc.contributor.alternativeName | 채선기 | - |
dc.contributor.alternativeName | 김정우 | - |
dc.contributor.alternativeName | 양영 | - |
dc.contributor.alternativeName | 임종석 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.identifier.bibliographicCitation | FEBS Letters, vol. 587, no. 22, pp. 3668-3674 | - |
dc.identifier.doi | 10.1016/j.febslet.2013.09.027 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Caspase | - |
dc.subject.keyword | DNase | - |
dc.subject.keyword | eIF3g | - |
dc.subject.keyword | Translation initiation factor | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.subject.local | Caspase | - |
dc.subject.local | Caspases | - |
dc.subject.local | caspase | - |
dc.subject.local | DNase | - |
dc.subject.local | eIF3g | - |
dc.subject.local | Translation initiation factor | - |
dc.description.journalClass | Y | - |
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