Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration = VDUP1의 간 재생에서의 priming phase 조절

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Title
Vitamin D3 up-regulated protein 1 controls the priming phase of liver regeneration = VDUP1의 간 재생에서의 priming phase 조절
Author(s)
H J Kwon; Sung Kuk Hong; Woon Kee YoonKi Hoan NamIn Pyo Choi; D Y Kim; Hyoung-Chin KimYoung Suk Won
Bibliographic Citation
Journal of Veterinary Science, vol. 14, no. 3, pp. 257-262
Publication Year
2013
Abstract
Vitamin D3 up-regulated protein 1 (VDUP1) is a potent growth suppressor that inhibits tumor cell proliferation and cell cycle progression when overexpressed. In a previous study, we showed that VDUP1 knockout (KO) mice exhibited accelerated liver regeneration because such animals could effectively control the expression of cell cycle regulators that drive the G1-to-S phase progression. In the present study, we further investigated the role played by VDUP1 in initial priming of liver regeneration. To accomplish this, VDUP1 KO and wild-type (WT) mice were subjected to 70% partial hepatectomy (PH) and sacrificed at different times after surgery. The hepatic levels of TNF-α and IL-6 increased after PH, but there were no significant differences between VDUP1 KO and WT mice. Nuclear factor-κB (NF-κB), c-Jun-N-terminal kinase (JNK), and signal transducer and activator of transcription 3 (STAT-3) were activated much earlier and to a greater extent in VDUP1 KO mice after PH. A single injection of TNF-α or IL-6 caused rapid activation of JNK and STAT-3 expression in both mice, but the responses were stronger and more sustained in VDUP1 KO mice. In conclusion, our findings provide evidence that VDUP1 plays a role in initiation of liver regeneration.
Keyword
C-Jun-N-terminal kinaseNF-κBPartial hepatectomySignal transducer and activator of transcription 3Vitamin D3 up-regulated protein 1
ISSN
I000-0131
Publisher
South Korea
DOI
http://dx.doi.org/10.4142/jvs.2013.14.3.257
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
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