Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition

Cited 28 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorMyung Jin Son-
dc.contributor.authorB R Jeong-
dc.contributor.authorYooJeong Kwon-
dc.contributor.authorYee Sook Cho-
dc.date.accessioned2017-04-19T09:45:36Z-
dc.date.available2017-04-19T09:45:36Z-
dc.date.issued2013-
dc.identifier.issn1357-2725-
dc.identifier.uri10.1016/j.biocel.2013.07.023ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11605-
dc.description.abstractThe switch in cell metabolism from oxidative phosphorylation to glycolysis is critical for the reprogramming of cells to pluripotency. Here, we demonstrate that the disturbance of mitochondrial metabolism by canonical mitochondrial inhibitors enhances metabolic reprogramming toward a glycolytic state, enabling the highly efficient generation of induced pluripotent stem cells. This interference with mitochondrial bioenergetics resulted in enriched reprogrammable subpopulations and accelerated the conversion of refractory intermediates to pluripotent states without requiring additional genetic or epigenetic modifications. Conversely, the reprogramming efficiency and accelerated reprogramming kinetics promoted by mitochondrial inhibition were obstructed by glycolysis inhibitors. We suggest that changes in mitochondrial bioenergetics are a novel mechanism involved in the regulation of cell fate and, more importantly, in the reprogramming of cells to pluripotency.-
dc.publisherElsevier-
dc.titleInterference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition-
dc.title.alternativeInterference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition-
dc.typeArticle-
dc.citation.titleInternational Journal of Biochemistry & Cell Biology-
dc.citation.number11-
dc.citation.endPage2518-
dc.citation.startPage2512-
dc.citation.volume45-
dc.contributor.affiliatedAuthorMyung Jin Son-
dc.contributor.affiliatedAuthorYooJeong Kwon-
dc.contributor.affiliatedAuthorYee Sook Cho-
dc.contributor.alternativeName손명진-
dc.contributor.alternativeName정보람-
dc.contributor.alternativeName권유정-
dc.contributor.alternativeName조이숙-
dc.identifier.bibliographicCitationInternational Journal of Biochemistry & Cell Biology, vol. 45, no. 11, pp. 2512-2518-
dc.identifier.doi10.1016/j.biocel.2013.07.023-
dc.subject.keywordBioenergetics-
dc.subject.keywordGlycolysis-
dc.subject.keywordiPSCs-
dc.subject.keywordMitochondria-
dc.subject.keywordReprogramming-
dc.subject.localBioenergetics-
dc.subject.localbioenergetics-
dc.subject.localglycolysis-
dc.subject.localGlycolysis-
dc.subject.localiPSCs-
dc.subject.localIPSCs-
dc.subject.localMitochondria-
dc.subject.localmitochondria-
dc.subject.localreprogramming-
dc.subject.localReprogramming-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.