A genome-wide resource of cell cycle and cell shape genes of fission yeast

Cited 92 time in scopus
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Title
A genome-wide resource of cell cycle and cell shape genes of fission yeast
Author(s)
J Hayles; V Wood; L Jeffery; K L Hoe; Dong Uk Kim; H O Park; S Salas-Pino; C Heichinger; P Nurse
Bibliographic Citation
Open Biology, vol. 3, no. 5, pp. 130053-130053
Publication Year
2013
Abstract
To identify near complete sets of genes required for the cell cycle and cell shape, we have visually screened a genome-wide gene deletion library of 4843 fission yeast deletion mutants (95.7% of total protein encoding genes) for their effects on these processes. A total of 513 genes have been identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. Deletions of a further 333 genes lead to specific alterations in cell shape and another 524 genes result in generally misshapen cells. Here, we provide the first eukaryotic resource of gene deletions, which describes a near genome-wide set of genes required for the cell cycle and cell shape
ISSN
2046-2441
Publisher
Royal Soc
DOI
http://dx.doi.org/10.1098/rsob.130053
Type
Article
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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