Decursin and doxorubicin are in synergy for the induction of apoptosis via STAT3 and/or mTOR pathways in human multiple myeloma cells

Cited 26 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJ Jang-
dc.contributor.authorS J Jeong-
dc.contributor.authorH Y Kwon-
dc.contributor.authorJ H Jung-
dc.contributor.authorE J Sohn-
dc.contributor.authorHyo Jung Lee-
dc.contributor.authorJ H Kim-
dc.contributor.authorS H Kim-
dc.contributor.authorJ H Kim-
dc.contributor.authorS H Kim-
dc.date.accessioned2017-04-19T09:46:12Z-
dc.date.available2017-04-19T09:46:12Z-
dc.date.issued2013-
dc.identifier.issn1741-427X-
dc.identifier.uri10.1155/2013/506324ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11629-
dc.description.abstractBackground. Combination cancer therapy is one of the attractive approaches to overcome drug resistance of cancer cells. In the present study, we investigated the synergistic effect of decursin from Angelica gigas and doxorubicin on the induction of apoptosis in three human multiple myeloma cells. Methodology/Principal Findings. Combined treatment of decursin and doxorubicin significantly exerted significant cytotoxicity compared to doxorubicin or decursin in U266, RPMI8226, and MM.1S cells. Furthermore, the combination treatment enhanced the activation of caspase-9 and -3, the cleavage of PARP, and the sub G1 population compared to either drug alone in three multiple myeloma cells. In addition, the combined treatment downregulated the phosphorylation of mTOR and its downstream S6K1 and activated the phosphorylation of ERK in three multiple myeloma cells. Furthermore, the combined treatment reduced mitochondrial membrane potential, suppressed the phosphorylation of JAK2, STAT3, and Src, activated SHP-2, and attenuated the expression of cyclind-D1 and survivin in U266 cells. Conversely, tyrosine phosphatase inhibitor pervanadate reversed STAT3 inactivation and also PARP cleavage and caspase-3 activation induced by combined treatment of doxorubicin and decursin in U266 cells. Conclusions/Significance. Overall, the combination treatment of decursin and doxorubicin can enhance apoptotic activity via mTOR and/or STAT3 signaling pathway in multiple myeloma cells.-
dc.publisherHindawi Ltd-
dc.titleDecursin and doxorubicin are in synergy for the induction of apoptosis via STAT3 and/or mTOR pathways in human multiple myeloma cells-
dc.title.alternativeDecursin and doxorubicin are in synergy for the induction of apoptosis via STAT3 and/or mTOR pathways in human multiple myeloma cells-
dc.typeArticle-
dc.citation.titleEvidence-Based Complementary and Alternative Medicine-
dc.citation.number0-
dc.citation.endPage506324-
dc.citation.startPage506324-
dc.citation.volume2013-
dc.contributor.affiliatedAuthorHyo Jung Lee-
dc.contributor.alternativeName장진실-
dc.contributor.alternativeName정수진-
dc.contributor.alternativeName권희영-
dc.contributor.alternativeName정지훈-
dc.contributor.alternativeName손은정-
dc.contributor.alternativeName이효정-
dc.contributor.alternativeName김지현-
dc.contributor.alternativeName김선희-
dc.contributor.alternativeName김진형-
dc.contributor.alternativeName김성훈-
dc.identifier.bibliographicCitationEvidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 506324-506324-
dc.identifier.doi10.1155/2013/506324-
dc.description.journalClassY-
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.