DC Field | Value | Language |
---|---|---|
dc.contributor.author | H S Kim | - |
dc.contributor.author | Y J Lee | - |
dc.contributor.author | H K Lee | - |
dc.contributor.author | J S Kim | - |
dc.contributor.author | Y Park | - |
dc.contributor.author | Jong Soon Kang | - |
dc.contributor.author | B Y Hwang | - |
dc.contributor.author | J T Hong | - |
dc.contributor.author | Y Kim | - |
dc.contributor.author | S B Han | - |
dc.date.accessioned | 2017-04-19T09:46:12Z | - |
dc.date.available | 2017-04-19T09:46:12Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | 10.1016/j.fct.2013.05.013 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/11630 | - |
dc.description.abstract | Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. In this study, we investigated the anti-inflammatory mechanisms of BISA in dendritic cells (DCs), which play an essential role in innate and adaptive immune responses. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. Taken together, our data suggest that BISA inhibited DC functions by blocking MAPK and NF-κB signaling. | - |
dc.publisher | Elsevier | - |
dc.title | Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-kappa B signaling | - |
dc.title.alternative | Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-kappa B signaling | - |
dc.type | Article | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 33 | - |
dc.citation.startPage | 26 | - |
dc.citation.volume | 59 | - |
dc.contributor.affiliatedAuthor | Jong Soon Kang | - |
dc.contributor.alternativeName | 김형숙 | - |
dc.contributor.alternativeName | 이영준 | - |
dc.contributor.alternativeName | 이홍경 | - |
dc.contributor.alternativeName | 김지성 | - |
dc.contributor.alternativeName | 박윤수 | - |
dc.contributor.alternativeName | 강종순 | - |
dc.contributor.alternativeName | 황방연 | - |
dc.contributor.alternativeName | 홍진태 | - |
dc.contributor.alternativeName | 김영수 | - |
dc.contributor.alternativeName | 한상배 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, vol. 59, pp. 26-33 | - |
dc.identifier.doi | 10.1016/j.fct.2013.05.013 | - |
dc.subject.keyword | Bisabolangelone | - |
dc.subject.keyword | Dendritic cells | - |
dc.subject.keyword | MAPKs | - |
dc.subject.keyword | NF-κB | - |
dc.subject.local | Bisabolangelone | - |
dc.subject.local | Dendritic cell | - |
dc.subject.local | Dendritic cells (DC) | - |
dc.subject.local | dendritic cells | - |
dc.subject.local | Dendritic cells (DCs) | - |
dc.subject.local | Dendritic cells | - |
dc.subject.local | dendritic cells (DC) | - |
dc.subject.local | dendritic cell | - |
dc.subject.local | MAPK | - |
dc.subject.local | MAPKs | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.description.journalClass | Y | - |
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