Butein is a novel anti-adipogenic compound

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Title
Butein is a novel anti-adipogenic compound
Author(s)
N J Song; H J Yoon; K H Kim; S R Jung; W S Jang; C R Seo; Y M Lee; D H Kweon; J W Hong; Jeong Soo Lee; K M Park; K R Lee; K W Park
Bibliographic Citation
Journal of Lipid Research, vol. 54, no. 5, pp. 1385-1396
Publication Year
2013
Abstract
Rhus verniciflua Stokes (RVS) has been used as a traditional herbal medicine for its various biological activities including anti-adipogenic effects. Activity-guided separation led to the identification of the anti-adipogenic functions of butein. Butein, a novel anti-adipogenic compound, robustly suppressed lipid accumulation and inhibited expression of adipogenic markers. Molecular studies showed that activated transforming growth factor- β (TGF- β ) and suppressed signal transducer and activator of transcription 3 (STAT3) signaling pathways were mediated by butein. Analysis of the temporal expression profiles suggests that TGF- β signaling precedes the STAT3 in the butein-mediated anti-adipogenic cascade. Small interfering RNA-mediated silencing of STAT3 or SMAD2/3 blunted the inhibitory effects of butein on adipogenesis indicating that an interaction between two signaling pathways is required for the action of butein. Upon butein treatments, stimulation of TGF- β signaling was still preserved in STAT3 silenced cells, whereas regulation of STAT3 signaling by butein was signifi- cantly impaired in SMAD2/3 silenced cells, further showing that TGF- β acts upstream of STAT3 in the butein-mediated anti-adipogenesis. Taken together, the present study shows that butein, a novel anti-adipogenic compound from RVS, inhibits adipocyte differentiation through the TGF- β pathway followed by STAT3 and peroxisome proliferatoractivated receptor γ signaling, further implicating potential roles of butein in TGF- β - and STAT3-dysregulated diseases.
Keyword
3T3-L1Adipocyte differentiationButeinC3H10T1/2GenisteinObesityPeroxisome proliferator-activated receptor γResveratrolRhus verniciflua Stokes
ISSN
0022-2275
Publisher
Amer Soc Biochemistry Molecular Biology Inc
DOI
http://dx.doi.org/10.1194/jlr.M035576
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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