A novel canine influenza H3N2 virus isolated from cats in an animal shelter

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Title
A novel canine influenza H3N2 virus isolated from cats in an animal shelter
Author(s)
H Y Jeoung; S I Lim; B H Shin; J A Lim; J Y Song; Dae Sub Song; B K Kang; H J Moon; D J An
Bibliographic Citation
Veterinary Microbiology, vol. 165, no. 3, pp. 281-286
Publication Year
2013
Abstract
The interspecies transmission of avian-origin H3N2 canine influenza virus (CIV) to dogs was first reported in 2007. The present study characterized a novel CIV H3N2 isolated from cats in an animal shelter. A comparative analysis of the deduced amino acid sequences of the A/Canine/Korea/CY009/2010(H3N2) (CY009) and A/Feline/Korea/FY028/2010 (H3N2) (FY028) strains isolated from dogs and cats, respectively, in the animal shelter identified point mutations in 18 amino acid positions within eight viral genes. Interestingly, CY009 and FY028 replicated well in specific pathogen-free embryonated chicken eggs and in mice, respectively. Mice infected with the FY028 strain exhibited significant over expression of IL-10, TNF-α, and IFN-γ (p < 0.001) at 3 days postinfection. Thus, an emergency monitoring system should be developed to identify influenza mutations that occur during interspecies transmission in companion animals and for continuous public health surveillance.
Keyword
CIVFelineH3N2
ISSN
0378-1135
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.vetmic.2013.03.021
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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