Penicillinolide A: a new anti-inflammatory metabolite from the marine fungus Penicillium sp. SF-5292

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Title
Penicillinolide A: a new anti-inflammatory metabolite from the marine fungus Penicillium sp. SF-5292
Author(s)
D S Lee; W Ko; T H Quang; K S Kim; J H Sohn; Jae-Hyuk JangJong Seog Ahn; Y C Kim; H Oh
Bibliographic Citation
Marine Drugs, vol. 11, no. 11, pp. 4510-4526
Publication Year
2013
Abstract
In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher's method. Penicillinolide A (1) inhibited the production of NO and PGE2 due to inhibition of the expression of iNOS and COX-2. Penicillinolide A (1) also reduced TNF-α, IL-1β and IL-6 production, and these anti-inflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of IκB-α, NF-κB nuclear translocation, and NF-κB DNA binding activity. In addition, using inhibitor tin protoporphyrin (SnPP), a competitive inhibitor of HO activity, it was verified that the inhibitory effects of compound 1 on the production of pro-inflammatory mediators and NF-κB DNA binding activity were partially associated with HO-1 expression through Nrf2 nuclear translocation.
Keyword
10-membered lactoneAnti-inflammatory effectHeme oxygenase-1Marine-derived fungiPenicillium sp.
ISSN
1660-3397
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/md11114510
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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