Inhibitory effects of Pycnogenol (French maritime pine bark extract) on airway inflammation in ovalbumin-induced allergic asthma

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Title
Inhibitory effects of Pycnogenol (French maritime pine bark extract) on airway inflammation in ovalbumin-induced allergic asthma
Author(s)
In Sik Shin; Na Rae Shin; Chan Mi Jeon; Ju Mi Hong; Ok-Kyoung Kwon; J C Kim; Sei-Ryang Oh; K W Hahn; Kyung Seop Ahn
Bibliographic Citation
Food and Chemical Toxicology, vol. 62, pp. 681-686
Publication Year
2013
Abstract
Pycnogenol® (PYC) is a standardized extracts from the bark of the French maritime pine (Pinus maritime) and used as a herbal remedy for various diseases. In this study, we evaluated the effects of PYC on airway inflammation using a model of ovalbumin (OVA)-induced allergic asthma and RAW264.7 cells. PYC decreased nitric oxide production and reduced the interleukine (IL)-1β and IL-6 levels in LPS-stimulated RAW264.7 cells. PYC also reduced the expression of inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9 and enhanced the expression of hemeoxygenase (HO)-1. In the in vivo experiment, PYC decreased the inflammatory cell count and the levels of IL-4, IL-5, IL-13, and immunoglobulin (Ig) E in BALF or serum. These results are consistent with the histological analysis findings, which showed that PYC attenuated the airway inflammation and mucus hypersecretion induced by OVA challenge. In addition, PYC enhanced the expression of HO-1. In contrast, PYC inhibited the elevated expression of iNOS and MMP-9 proteins induced by OVA challenge. In conclusion, PYC exhibits protective effects against OVA-induced asthma and LPS-stimulated RAW264.7 cells. These results suggest that PYC has potential as a therapeutic agent for the treatment of allergic asthma.
Keyword
AsthmaFrench maritime pine barkInflammationPycnogenol®
ISSN
0278-6915
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.fct.2013.09.032
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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