Insulin/IGF signaling-related gene expression in the brain of a sporadic Alzheimer's disease monkey model induced by intracerebroventricular injection of streptozotocin

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dc.contributor.authorYoungjeon Lee-
dc.contributor.authorYoung-Hyun Kim-
dc.contributor.authorSang Je Park-
dc.contributor.authorJae Won Huh-
dc.contributor.authorSang-Hyun Kim-
dc.contributor.authorSun-Uk Kim-
dc.contributor.authorJi-Su Kim-
dc.contributor.authorKang Jin Jeong-
dc.contributor.authorK M Lee-
dc.contributor.authorY Hong-
dc.contributor.authorSang Rae Lee-
dc.contributor.authorKyu Tae Chang-
dc.date.accessioned2017-04-19T09:47:08Z-
dc.date.available2017-04-19T09:47:08Z-
dc.date.issued2014-
dc.identifier.issn1387-2877-
dc.identifier.uri10.3233/JAD-130776ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11678-
dc.description.abstractWe reported previously that the intracerebroventricular streptozotocin (icv-STZ)-treated cynomolgus monkey showed regionally specific glucose hypometabolism in FDG-PET imaging, similar to that observed in the early stages of sporadic Alzheimer's disease (sAD). However, further pathological analyses of this model at the molecular level are needed to validate it as a feasible model for sAD. Two cynomolgus monkeys were injected with 2 mg/kg STZ into the cerebellomedullary cistern at day 1, 7 and 14. Two control monkeys were given normal saline. At 5 months after injection, the expression levels of genes encoding 9 upstream molecules in insulin/insulin-like growth factor (IGF) signaling and markers for 4 cell-type populations in the frontal cortex, hippocampus, posterior cingulate, precuneus, and occipital cortex of control and icv-STZ treated cynomolgus monkeys were examined. Real-time quantitative PCR analyses demonstrated that the overall mRNA expression of insulin/IGF signaling-related genes was mainly impaired in the anterior part of the cerebrum, frontal cortex, and hippocampus, similar to the early stage of sAD. The changes were accompanied by the loss of oligodendrocytes and neurons. The posterior part of the cerebrum did not show degenerative alterations. The present study provides important fundamental information on the icv-STZ monkey model for sAD. These results may help guide future studies using this model for the investigation of pathological mechanisms and the development of drugs for sAD.-
dc.publisherIOS Press-
dc.titleInsulin/IGF signaling-related gene expression in the brain of a sporadic Alzheimer's disease monkey model induced by intracerebroventricular injection of streptozotocin-
dc.title.alternativeInsulin/IGF signaling-related gene expression in the brain of a sporadic Alzheimer's disease monkey model induced by intracerebroventricular injection of streptozotocin-
dc.typeArticle-
dc.citation.titleJournal of Alzheimers Disease-
dc.citation.number2-
dc.citation.endPage267-
dc.citation.startPage251-
dc.citation.volume38-
dc.contributor.affiliatedAuthorYoungjeon Lee-
dc.contributor.affiliatedAuthorYoung-Hyun Kim-
dc.contributor.affiliatedAuthorSang Je Park-
dc.contributor.affiliatedAuthorJae Won Huh-
dc.contributor.affiliatedAuthorSang-Hyun Kim-
dc.contributor.affiliatedAuthorSun-Uk Kim-
dc.contributor.affiliatedAuthorJi-Su Kim-
dc.contributor.affiliatedAuthorKang Jin Jeong-
dc.contributor.affiliatedAuthorSang Rae Lee-
dc.contributor.affiliatedAuthorKyu Tae Chang-
dc.contributor.alternativeName이영전-
dc.contributor.alternativeName김영현-
dc.contributor.alternativeName박상제-
dc.contributor.alternativeName허재원-
dc.contributor.alternativeName김상현-
dc.contributor.alternativeName김선욱-
dc.contributor.alternativeName김지수-
dc.contributor.alternativeName정강진-
dc.contributor.alternativeName이경민-
dc.contributor.alternativeName홍용근-
dc.contributor.alternativeName이상래-
dc.contributor.alternativeName장규태-
dc.identifier.bibliographicCitationJournal of Alzheimers Disease, vol. 38, no. 2, pp. 251-267-
dc.identifier.doi10.3233/JAD-130776-
dc.subject.keywordAlzheimer's disease-
dc.subject.keywordbrain-
dc.subject.keywordinsulin-
dc.subject.keywordmonkey-
dc.subject.keywordreal-time quantitative polymerase chain reaction-
dc.subject.keywordstreptozotocin-
dc.subject.localalzheimer's disease-
dc.subject.localAlzheimer’s disease (AD)-
dc.subject.localAlzheimer’s disease-
dc.subject.localAlzheimer's Disease-
dc.subject.localAlzheimer disease-
dc.subject.localAlzheimer's disease (AD)-
dc.subject.localAlzheimer′s disease-
dc.subject.localAlzheimer's disease-
dc.subject.localBrain-
dc.subject.localbrain-
dc.subject.localinsulin-
dc.subject.localInsulin-
dc.subject.localmonkey-
dc.subject.localMonkey-
dc.subject.localReal-time quantitative PCR-
dc.subject.localreal-time quantitative polymerase chain reaction-
dc.subject.localreal-time quantitative PCR-
dc.subject.localstreptozotocin-
dc.subject.localstreptozotocin (STZ)-
dc.subject.localStreptozotocin-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
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