Protein tyrosine phosphatase profiling studies during brown adipogenic differentiation of mouse primary brown preadipocytes

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dc.contributor.authorHye-Ryung Choi-
dc.contributor.authorWon Kon Kim-
dc.contributor.authorAnna Park-
dc.contributor.authorHyeyun Jung-
dc.contributor.authorBaek Soo Han-
dc.contributor.authorSang Chul Lee-
dc.contributor.authorKwang-Hee Bae-
dc.date.accessioned2017-04-19T09:47:16Z-
dc.date.available2017-04-19T09:47:16Z-
dc.date.issued2013-
dc.identifier.issn12258687-
dc.identifier.uri10.5483/BMBRep.2013.46.11.058ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/11685-
dc.description.abstractThere is a correlation between obesity and the amount of brown adipose tissue; however, the molecular mechanism of brown adipogenic differentiation has not been as extensively studied. In this study, we performed a protein tyrosine phosphatase (PTP) profiling analysis during the brown adipogenic differentiation of mouse primary brown preadipocytes. Several PTPs, including PTPRF, PTPRZ, and DUSP12 showing differential expression patterns were identified. In the case of DUSP12, the expression level is dramatically downregulated during brown adipogenesis. The ectopic expression of DUSP12 using a retroviral expression system induces the suppression of adipogenic differentiation, whereas a catalytic inactive DUSP12 mutant showed no effect on differentiation. These results suggest that DUSP12 is involved in brown adipogenic differentiation and may be used as a target protein for the treatment or prevention of obesity by the regulation of brown adipogenic differentiation.-
dc.publisherSouth Korea-
dc.titleProtein tyrosine phosphatase profiling studies during brown adipogenic differentiation of mouse primary brown preadipocytes-
dc.title.alternativeProtein tyrosine phosphatase profiling studies during brown adipogenic differentiation of mouse primary brown preadipocytes-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number11-
dc.citation.endPage543-
dc.citation.startPage539-
dc.citation.volume46-
dc.contributor.affiliatedAuthorWon Kon Kim-
dc.contributor.affiliatedAuthorBaek Soo Han-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.alternativeName최혜령-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName박안나-
dc.contributor.alternativeName정혜윤-
dc.contributor.alternativeName한백수-
dc.contributor.alternativeName이상철-
dc.contributor.alternativeName배광희-
dc.identifier.bibliographicCitationBMB Reports, vol. 46, no. 11, pp. 539-543-
dc.identifier.doi10.5483/BMBRep.2013.46.11.058-
dc.subject.keywordAdipogenesis-
dc.subject.keywordBrown adipocytes-
dc.subject.keywordDusp12-
dc.subject.keywordObesity-
dc.subject.keywordProtein tyrosine phosphatases-
dc.subject.localAdipogenesis-
dc.subject.localBrown adipocytes-
dc.subject.localBrown adipocyte-
dc.subject.localDusp12-
dc.subject.localObesity-
dc.subject.localProtein tyrosine phosphatases-
dc.subject.localProtein tyrosine phosphatase-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
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